• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Society for Gynecologic Investigation >Cerebrovascular hemodynamics in chronic hypertensive pregnant women who later develop superimposed preeclampsia.
【24h】

Cerebrovascular hemodynamics in chronic hypertensive pregnant women who later develop superimposed preeclampsia.

机译：慢性高血压孕妇的脑血管血流动力学，后来发展为先兆子痫。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: We have previously shown that normotensive pregnant women who later develop preeclampsia demonstrate lower baseline pulsatility index (PI) and resistance index (RI) but normal vasodilatory responses to stimulation tests. In the current study, we tested the hypothesis that women with chronic hypertension who later developed superimposed preeclampsia behave similarly. METHODS: Transcranial Doppler ultrasound was performed on 17 women with chronic hypertension during the second trimester of pregnancy to measure middle cerebral artery (MCA) velocities. Superimposed preeclampsia developed in seven patients (SUPER group) while the rest did not develop preeclampsia (CHT group). Measurements were performed in the left lateral position at baseline on room air, during 5% CO2 inhalation, and during a 2-minute isometric handgrip test. Blood pressure, heart rate, O2 saturation, and end-tidal PCO2 were recorded with each Doppler measurement. Mean PI, RI, and cerebral perfusion pressure (CPP) at each time were compared using two-way repeated measures analysis of variance. Statistical significance was set at P < .05. RESULTS: The women who developed superimposed preeclampsia did this an average of 8.7 +/- 1.3 weeks after the study. MCA PI and RI were lower, and CPP higher, in the SUPER group compared to the CHT group (0.64, 0.46, and 80.7 vs 0.74, 0.51, and 63.6, respectively; P < .05). Both maneuvers caused reduction in MCA PI and RI in both groups, whereas CPP increased only in the SUPER group. CONCLUSIONS: These findings suggest that women destined to develop preeclampsia have cerebral hemodynamic changes that predate the development of overt preeclampsia.
机译：目的：我们以前已经证明，后来发展为先兆子痫的血压正常的孕妇表现出较低的基线搏动指数（PI）和抵抗指数（RI），但对刺激试验的血管舒张反应正常。在当前的研究中，我们检验了以下假设，即后来发展为先兆子痫的慢性高血压妇女的行为类似。方法：在妊娠中期，对17名患有慢性高血压的妇女进行了经颅多普勒超声检查，以测量大脑中动脉（MCA）的速度。叠加性先兆子痫在七名患者中发生（SUPER组），其余未发生子痫前期（CHT组）。在室内空气中，吸入5％CO2的过程中以及在2分钟的等距手柄测试中，在左侧水平位置进行测量。每次多普勒测量均记录血压，心率，O2饱和度和潮气末PCO2。使用双向重复测量方差分析比较每次的平均PI，RI和脑灌注压（CPP）。统计学显着性设定为P <.05。结果：在研究后平均发展为先兆子痫的妇女平均做了8.7 +/- 1.3周。与CHT组相比，SUPER组的MCA PI和RI较低，而CPP较高（分别为0.64、0.46和80.7与0.74、0.51和63.6; P <.05）。两种方法均导致两组MCA PI和RI降低，而CPP仅在SUPER组增加。结论：这些发现表明注定要发展先兆子痫的妇女的脑血流动力学改变早于先兆子痫的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号