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首页> 外文期刊>Journal of the Society for Gynecologic Investigation >Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction.
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Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction.

机译：人胎盘过氧化物酶体增殖物激活的受体δ和γ在健康妊娠，先兆子痫和子宫内生长受限中的表达。

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OBJECTIVES: Human and animal studies have demonstrated that peroxisome proliferator-activated receptors (PPARs) are important in placental development and play key roles in metabolism and inflammation. We studied placental PPARdelta, PPARgamma, and retinoid X receptor alpha (RXRalpha) expression in healthy pregnancy and in preeclampsia (PET) and intrauterine growth restriction (IUGR). METHODS AND RESULTS: Using immunocytochemistry, PPARdelta, PPARgamma, and RXRalpha were localized to the cyto- and syncytiotrophoblast and invading trophoblast columns in first and second trimester placentas. Third trimester placentas from healthy pregnancy, and in PET and IUGR, demonstrated PPARdelta, PPARgamma, and RXRalpha staining within the syncytium, and localization within isolated cells in the stroma. In uncomplicated pregnancies, PPARdelta mRNA expression (PPARdelta:18s ratio, third trimester median 0.43 [interquartile (IQ) range 0.26-0.52] vs first trimester 0.20 [0.00-0.26], P = .03) and PPARdelta protein expression (third trimester 3.94 [2.45-4.68] vs first trimester 1.29 [0.78-2.29] optical densitometry [OD] mm(2), P = .04) were higher in the third trimester than in the first trimester. There were no consistent differences in PPARdelta, PPARgamma, or RXRalpha mRNA and protein expression among PET or IUGR placentas and controls. CONCLUSION: PPARdelta expression is up-regulated between the first and third trimester, indicating a role for this nuclear receptor in placental function. We found no evidence that placental PPARdelta, PPARgamma, and RXRalpha expression is changed in PET or IUGR. This suggests that changes in total placental PPAR expression are not involved in the pathophysiology of these conditions.
机译：目的：人类和动物研究表明，过氧化物酶体增殖物激活受体（PPAR）在胎盘发育中很重要，并且在新陈代谢和炎症中起关键作用。我们研究了健康妊娠，子痫前期（PET）和宫内生长受限（IUGR）中的胎盘PPARδ，PPARγ和类维生素A X受体α（RXRalpha）表达。方法和结果：使用免疫细胞化学方法，将PPARdelta，PPARgamma和RXRalpha定位于早孕中期和中期妊娠胎盘中的细胞和合体滋养层，并侵袭滋养层。来自健康怀孕的晚期三个月胎盘以及在PET和IUGR中显示合胞体内的PPARdelta，PPARgamma和RXRalpha染色以及基质中分离细胞内的定位。在简单的妊娠中，PPARdelta mRNA表达（PPARdelta：18s比率，孕中期中位数0.43 [四分位数（IQ）范围0.26-0.52]与孕中期0.20 [0.00-0.26]，P = .03）和PPARdelta蛋白表达（孕中期3.94） [2.45-4.68] vs孕早期1.29 [0.78-2.29]光学密度[OD] mm（2），P = .04）在孕晚期比孕早期更高。在PET或IUGR胎盘与对照组之间，PPARdelta，PPARgamma或RXRalpha mRNA和蛋白质表达没有一致的差异。结论：PPARδ的表达在孕早期和孕中期之间上调，表明该核受体在胎盘功能中的作用。我们没有发现证据表明在PET或IUGR中胎盘PPARdelta，PPARgamma和RXRalpha表达发生改变。这表明胎盘PPAR总表达的变化不涉及这些疾病的病理生理。

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