Synthesis of 3-(benzimidazol-2-yl-amino)-1-(4-bromophenyl)-2-thioxopyrimidin-4,6-dione analogs and their antimicrobial activity

N. M. Goudgaon; N. Jeelan Basha

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Synthesis of 3-(benzimidazol-2-yl-amino)-1-(4-bromophenyl)-2-thioxopyrimidin-4,6-dione analogs and their antimicrobial activity

机译：3-（苯并咪唑-2-基-氨基）-1-（4-溴苯基）-2-硫代嘧啶-4,6-二酮类似物的合成及其抗菌活性

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3-(Benzimidazol-2-yl-amino)-5-(substituted benzylidene)-1-(4-bromophenyl)-2-thioxopyrimidin-4,6-dione (4a-e) and 5-(2-substituted phenylhydrazono)-3-(benzimidazol-2-yl-amino)-1-(4-bromophenyl)-2-thioxopyrimidine-4,6-dione (5a-c) were synthesized in three steps. Reaction of 2-hydrazinobenzimidazole (1) with 4-bromophenyl isothiocyanate gave 1-(benzimidazol-2-yl-amino)-4-(4-bromophenyl)thiosemicarbazide (2) which on cyclization with malonic acid in presence of acetyl chloride furnished 3-(benziraidazol-2-yl-amino)-1-(4-bromophenyl)-2-thioxopyriniidin-4,6-dione (3). Further, reaction of 3 with aryl aldehydes and diazonium salt of arylamines yielded desired compounds 4a-e and 5a-c in 52-72% yield. All the systhesized compounds have been characterized by spectral data's and they are screened for anti-microbial activity.

机译：3-（苯并咪唑-2-基-氨基）-5-（取代的亚苄基）-1-（4-溴苯基）-2-噻吩并嘧啶-4,6-二酮（4a-e）和5-（2-取代的苯基肼基）通过三个步骤合成了-3-（苯并咪唑-2-基-氨基）-1-（4-溴苯基）-2-硫代嘧啶-4,6-二酮（5a-c）。 2-肼基苯并咪唑（1）与异硫氰酸4-溴苯酯的反应生成1-（苯并咪唑-2-基-氨基）-4-（4-溴苯基）硫代氨基脲（2），将其在丙二酸存在下与丙二酸环化，得到乙酰氯3 -（苯甲ira唑-2-基-氨基）-1-（4-溴苯基）-2-硫代吡喃吡啶-4,6-二酮（3）。此外，使3与芳基醛和芳基胺的重氮盐反应，以52-72％的产率得到所需的化合物4a-e和5a-c。所有合成的化合物均已通过光谱数据表征，并筛选了其抗微生物活性。

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《Journal of the Indian Chemical Society》 |2010年第8期|共6页
作者
N. M. Goudgaon; N. Jeelan Basha;
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正文语种 eng
中图分类化学;
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2-Substituted benzimidazole; thiosemicarbazide; 2-thiobarbituric acid; antibacterial; antifungal.;

机译：2-取代的苯并咪唑;硫代氨基脲;2-硫代巴比妥酸;抗菌;抗真菌药。;

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1. Synthesis of 3-(benzimidazol-2-yl-amino)-1-(4-bromophenyl)-2-thioxopyrimidin-4,6-dione analogs and their antimicrobial activity [J] . N. M. Goudgaon, N. Jeelan Basha Journal of the Indian Chemical Society . 2010,第8期

机译：3-（苯并咪唑-2-基-氨基）-1-（4-溴苯基）-2-硫代嘧啶-4,6-二酮类似物的合成及其抗菌活性
2. Synthesis, X-ray Characterization and Antimicrobial Activity of (3-(4-bromophenyl)oxiran-2-yl)(2,4-dichlorophenyl)methanone [J] . Mona A. Alsafi, Eman M. Flefel, Nermeen S. Abbas, Journal of computational and theoretical nanoscience . 2018,第2期

机译：（3-（4-溴苯基）氧化兰-2-基）（2,4-二氯苯基）甲基酮的合成，X射线表征和抗微生物活性
3. Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 2-[(8-hydroxyquinolinyl)-5-aminomethyl] 3-(4-Bromophenyl)-3(H)- quinazolin-4-one. [J] . R. T. Vashi, S. B. Patel, H. K. Kadiya Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry . 2012,第4期

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4. Synthesis of (2E)-3-(4-bromophenyl)-1-(3, 4-dichlorophenyl) prop-2-en-1-one and characterization [C] . Rashmi Madhava, J. Indira, Balladka Kunhanna Sarojini, International Conference on Physics of Materials and Nanotechnology . 2020

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机译：合成，光谱研究，量子化学研究（ AB-INITIO ＆DFT）和抗微生物活性为3-（3-氯-4,5-二甲氧基 - 苯基）-1-（4,5-二甲氧基-2-甲基苯基）PROP-2-EN-1-1

Synthesis of 3-(benzimidazol-2-yl-amino)-1-(4-bromophenyl)-2-thioxopyrimidin-4,6-dione analogs and their antimicrobial activity

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