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首页> 外文期刊>Journal of synchrotron radiation >A survey of global radiation damage to 15 different protein crystal types at room temperature: A new decay model
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A survey of global radiation damage to 15 different protein crystal types at room temperature: A new decay model

机译：在室温下对15种不同蛋白质晶体的全球辐射损害的调查：一种新的衰变模型

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摘要

The radiation damage rates to crystals of 15 model macromolecular structures were studied using an automated radiation sensitivity characterization procedure. The diffracted intensity variation with dose is described by a two-parameter model. This model includes a strong resolution-independent decay specific to room-temperature measurements along with a linear increase in overall Debye-Waller factors. An equivalent representation of sensitivity via a single parameter, normalized half-dose, is introduced. This parameter varies by an order of magnitude between the different structures studied. The data show a correlation of crystal radiation sensitivity with crystal solvent content but no dose-rate dependency was detected in the range 0.05-300 kGy s~(-1). The results of the crystal characterization are suitable for either optimal planning of room-temperature data collection or in situ crystallization plate screening experiments.
机译：使用自动辐射敏感性表征程序研究了15种模型大分子晶体对晶体的辐射损伤率。衍射强度随剂量的变化用两参数模型描述。该模型包括特定于室温的强分辨率无关衰减，以及整个Debye-Waller因子的线性增加。介绍了通过单个参数（标准化半剂量）的灵敏度的等效表示。在所研究的不同结构之间，该参数变化了一个数量级。数据显示晶体辐射敏感性与晶体溶剂含量之间的相关性，但在0.05-300 kGy s〜（-1）范围内未检测到剂量率依赖性。晶体表征的结果适用于室温数据收集的最佳计划或原位结晶板筛选实验。

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