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首页> 外文期刊>Journal of the Royal Society Interface >Quantifying the roles of cell motility and cell proliferation in a circular barrier assay
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Quantifying the roles of cell motility and cell proliferation in a circular barrier assay

机译：在循环屏障测定中定量细胞活力和细胞增殖的作用

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摘要

Moving fronts of cells are essential features of embryonic development, wound repair and cancer metastasis. This paper describes a set of experiments to investigate the roles of random motility and proliferation in driving the spread of an initially confined cell population. The experiments include an analysis of eel spreading when proliferation was inhibited. Our data have been analysed using two mathematical models: a lattice-based discrete model and a related continuum partial differential equation model. We obtain independent estimates of the random motility parameter, D, and the intrinsic proliferation rate, A, and we confirm that these estimates lead to accurate modelling predictions of the position of the leading edge of the moving front as well as the evolution of the cell density profiles. Previous work suggests that systems with a high A/D ratio will be characterized by steep fronts, whereas systems with a low A/D ratio will lead to shallow diffuse fronts and this is confirmed in the present study. Our results provide evidence that continuum models, based on the Fisher-Kolmogorov equation, are a reliable platform upon which we can interpret and predict such experimental observations.
机译：细胞的移动前沿是胚胎发育，伤口修复和癌症转移的基本特征。本文介绍了一组实验，以研究随机运动性和增殖在驱动最初受限细胞群扩散中的作用。实验包括对增殖受到抑制时鳗鱼扩散的分析。我们的数据已使用两个数学模型进行了分析：基于格的离散模型和相关的连续统偏微分方程模型。我们获得了随机运动参数D和固有增殖率A的独立估计，并且我们确认这些估计可导致对运动前沿的前沿位置以及细胞进化的准确建模预测密度分布图。先前的工作表明，具有高A / D比的系统将具有陡峭的前沿，而具有低A / D比的系统将导致较浅的扩散前沿，这一点在本研究中得到了证实。我们的结果提供了证据，表明基于Fisher-Kolmogorov方程的连续模型是可靠的平台，我们可以在该平台上解释和预测此类实验观察结果。

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