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首页> 外文期刊>Journal of Veterinary Dentistry >Sublingual Reactive Histiocytosis in a Dog
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Sublingual Reactive Histiocytosis in a Dog

机译：犬舌下反应性组织细胞增生症

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摘要

Lingual lesions are relatively uncommon in dogs and are mostly represented by neoplasms and glossitis secondary to trauma or infections. Reactive histiocytosis is an uncommon, poorly understood, reactive disorder characterized by proliferation of activated, interstitial, dendritic, antigen-presenting cells associated with lymphocytes and neutrophils with a specific angiocentric orientation and occasional angioinvasion and angio-destruction. Clinically, the disease has a waxing and waning behavior with possible response to treatment and regression, or agression to multiple lesions and internal organ involvement. This case report describes an unusual sublingual presentation of reactive histiocytosis in a Miniature Pinscher dog. The diagnosis was obtained by clinical and histopathological exclusion of other causes, detection of the characteristic microscopic growth pattern, and by immunocytochemistry. Histiocytic cells were vimentin, CD 18, CDllc, and CD lc positive consistent with a dendritic cell origin. Anti-BCG stain (Bacillus Calmette and Guerin) was negative for etiological agents. The dog was treated with oral administration of tetracycline and niacinamide during an 8-month period. There was no indication of recurrence of the sublingual mass 2-years following treatment.
机译：狗的舌部病变相对少见，主要表现为继发于创伤或感染的肿瘤和舌炎。反应性组织细胞增生是一种罕见的，知之甚少的反应性疾病，其特征在于与淋巴细胞和嗜中性粒细胞相关的活化的，间质性，树突状，抗原呈递细胞的增殖，其具有特定的血管中心方向，偶有血管浸润和血管破坏。在临床上，该疾病具有蜡化和减弱的行为，可能对治疗和消退有反应，或者对多个病变和内脏器官受累。该病例报告描述了一只小型Pinscher狗的反应性组织细胞增多症的一种不常见的舌下表现。通过临床和组织病理学排除其他原因，检测特征性显微镜生长模式以及通过免疫细胞化学获得诊断。组织细胞是波形蛋白，CD 18，CD11c和CD1c阳性，与树突状细胞起源一致。抗BCG染色（芽孢杆菌和游击芽孢杆菌）对病原体呈阴性。在8个月的时间里给狗口服四环素和烟酰胺治疗。治疗后2年没有舌下肿块复发的迹象。

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