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首页> 外文期刊>Journal of Theoretical Biology >Intramitotic and Intraclonal Variation in Proliferative Potential of Human Diploid Cells: Explained by Telomere Shortening
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Intramitotic and Intraclonal Variation in Proliferative Potential of Human Diploid Cells: Explained by Telomere Shortening

机译：人二倍体细胞增殖潜能的有丝分裂和克隆内变化：端粒缩短解释。

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摘要

Normal human diploid cells can only divide for a limited number of times (known as the Hayflick limit). They manifest two unique features during in vitro senescence. The division capability of individual cells in a clone, though all derived from a same ancestor, is heterogeneous with a distinct bimodal distribution. Two sister cells derived from a same parent cell can have a large difference in their doubling potentials. These two unique features have not been properly explained by any known physiological process since their observation in 1980. Here I represent a telomere-shortening model based on recent experimental measurement of telomere deletion in human cells. Using computer simulation, I show that the model satisfactorily explains the intraclonal and intramitotic variation in division capability of human diploid cells. Moreover, the simulations predict that human cells may only monitor the shortening of a few, most likely two, telomeres to regulate their proliferative potential.
机译：正常的人类二倍体细胞只能分裂有限的次数（称为Hayflick极限）。它们在体外衰老过程中表现出两个独特的特征。尽管克隆中单个细胞的分裂能力均来自同一个祖先，但它们的分裂能力是异质的，具有独特的双峰分布。源自同一亲本细胞的两个姐妹细胞的倍增电位可能存在很大差异。自从1980年观察到这两个独特的特征以来，还没有任何已知的生理过程对其进行适当的解释。在此，我代表一种基于最近在人体细胞中端粒缺失的实验测量结果的端粒缩短模型。使用计算机仿真，我表明该模型可以令人满意地解释人二倍体细胞分裂能力的克隆内和有丝分裂变化。此外，模拟预测人类细胞可能仅监测少数（最可能是两个）端粒的缩短来调节其增殖潜能。

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