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Transcriptional frequency and cell determination

机译：转录频率和细胞确定

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The relative base composition of DNA regulatory sequences of certain genes of undetermined multipotent progenitor cells may account for the frequency of transcription of these genes in cell determination. The sequences of these regulatory regions of cell determination genes that are more AT-rich would create the potential for transcription at a higher frequency due to their lower melting temperature, as well as propensity to bend. An increase of one or more of the high mobility group (HMG) chromatin proteins would preferentially bind the more AT-rich regulatory sequences, thereby increasing the rate of transcription. The amount of unphosphorylated H1 historic reacting with these same regulatory sites may decrease transcription frequency. The level of cell growth, i.e. total protein synthesis of a cell, is correlated positively with the synthesis of HMG proteins. H1 histone synthesis is linked to DNA replication. Unbalanced growth would alter the amounts of HMG proteins and H1 histone, thus changing transcriptional frequency. The greater the enrichment of AT sequences in the regulatory regions of the cell determination genes, the greater may be the extent of evolutionary conservation. Higher frequency of transcription of the cell determination genes with the more AT-rich regulatory sequences could account for the earlier expression of the more conserved cell determination genes during embryonic development. Preferential binding of HI histone to the more AT-rich regulatory sequences would subsequently restrict their transcription before that of less conserved cell determination genes. (C) 2004 Elsevier Ltd. All rights reserved.
机译：未确定的多能祖细胞某些基因的DNA调控序列的相对碱基组成可能解释了这些基因在细胞测定中的转录频率。 AT含量更高的细胞测定基因的这些调节区的序列由于其较低的解链温度和弯曲倾向而具有较高的转录潜能。一种或多种高迁移率族（HMG）染色质蛋白的增加将优先结合更多AT富集的调控序列，从而提高转录速率。与这些相同调节位点历史性反应的未磷酸化的H1的量可能降低转录频率。细胞生长的水平，即细胞的总蛋白合成，与HMG蛋白的合成呈正相关。 H1组蛋白的合成与DNA复制有关。不平衡的生长会改变HMG蛋白和H1组蛋白的量，从而改变转录频率。在细胞测定基因的调节区中AT序列的富集程度越大，进化保守的程度就越大。具有更多AT富集调控序列的细胞测定基因的较高转录频率可以解释胚胎发育过程中更保守的细胞测定基因的较早表达。 HI组蛋白与AT含量更高的调节序列的优先结合将随后限制其转录，而保守性较低的细胞测定基因则受到限制。 （C）2004 Elsevier Ltd.保留所有权利。

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