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首页> 外文期刊>Journal of Theoretical Biology >Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung
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Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung

机译：胚胎肺中蠕动液体组织动力学的形态学意义

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Peristalsis begins in the lung as soon as the smooth muscle forms, and persists until birth. Since the prenatal lung is liquid-filled, smooth muscle action can deform tissues and transport fluid far from the immediately adjacent tissues. Stretching of embryonic tissues and sensation of internal fluid flows have been shown to have potent morphogenetic effects. We hypothesize that these effects are at work in lung morphogenesis. To place that hypothesis in a quantitative framework, we analyze a model of the fluid-structure interactions between embryonic tissues and lumen fluid resulting from peristaltic waves that partially occlude the airway. We find that if the airway is closed, deformations are synchronized; by contrast, if the trachea is open, maximal occlusion precedes maximal pressure. We perform a parametric analysis of how occlusion, stretch, and flow depend on tissue stiffnesses, smooth muscle force, tissue shape and size, and fluid viscosity. We find that most of these relationships are governed by simple ratios. (C) 2015 Elsevier Ltd. All rights reserved.
机译：平滑肌一旦形成，蠕动就会在肺部开始，并一直持续到出生。由于产前肺部充满液体，平滑肌的作用会使组织变形并使流体远离紧邻的组织。胚胎组织的拉伸和内部流体流动的感觉已被证明具有有效的形态发生作用。我们假设这些作用在肺形态发生中起作用。为了将该假设置于定量框架中，我们分析了一种模型，该模型由部分阻塞气道的蠕动波引起的胚胎组织与管腔液之间的流体-结构相互作用。我们发现，如果气道关闭，变形是同步的。相反，如果气管张开，则最大阻塞先于最大压力。我们执行参数分析，分析阻塞，伸展和流动如何取决于组织刚度，平滑肌力，组织形状和大小以及流体粘度。我们发现，大多数关系都由简单比率控制。 （C）2015 Elsevier Ltd.保留所有权利。

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