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Nonlinear mechanical modeling of cell adhesion

机译：细胞粘附的非线性力学建模

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Cell adhesion, which is mediated by the receptor-ligand bonds, plays an essential role in various biological processes. Previous studies often described the force-extension relationship of receptor-ligand bond with linear assumption. However, the force-extension relationship of the bond is intrinsically nonlinear, which should have significant influence on the mechanical behavior of cell adhesion. In this work, a nonlinear mechanical model for cell adhesion is developed, and the adhesive strength was studied at various bond distributions. We find that the nonlinear mechanical behavior of the receptor-ligand bonds is crucial to the adhesive strength and stability. This nonlinear behavior allows more bonds to achieve large bond force simultaneously, and therefore the adhesive strength becomes less sensitive to the change of bond density at the outmost periphery of the adhesive area. In this way, the strength and stability of cell adhesion are soundly enhanced. The nonlinear model describes the cell detachment behavior better than the linear model. (C) 2007 Elsevier Ltd. All rights reserved.
机译：由受体-配体键介导的细胞粘附在各种生物学过程中起着至关重要的作用。以前的研究经常用线性假设描述受体-配体键的力-延伸关系。但是，键的力-延伸关系本质上是非线性的，这应该对细胞粘附的机械行为产生重大影响。在这项工作中，建立了细胞粘附的非线性力学模型，并研究了在各种键分布下的粘附强度。我们发现受体-配体键的非线性力学行为对粘合强度和稳定性至关重要。这种非线性行为允许更多的粘合同时实现大的粘合力，因此粘合强度对粘合区域最外围的粘合密度的变化变得不那么敏感。以这种方式，细胞粘附的强度和稳定性得到了显着增强。非线性模型比线性模型更好地描述了细胞脱离行为。 （C）2007 Elsevier Ltd.保留所有权利。

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