...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Theoretical Biology >Mutual interaction in network motifs robustly sharpens gene expression in developmental processes.
【24h】

Mutual interaction in network motifs robustly sharpens gene expression in developmental processes.

机译：网络基序中的相互作用会在发育过程中强烈增强基因表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The gene regulatory network of a developmental process contains many mutually repressive interactions between two genes. They are often regulated by or regulate an additional factor, which constitute prominent network motifs, called regulated and regulating mutual loops. Our database analysis on the gene regulatory network for Drosophila melanogaster indicates that those with mutual repression are working specifically for the segmentation process. To clarify their biological roles, we mathematically study the response of the regulated mutual loop with mutual repression to input stimuli. We show that the mutual repression increases the response sensitivity without affecting the threshold input level to activate the target gene expression, as long as the network output is unique for a given input level. This high sensitivity of the motif can contribute to sharpening the spatial domain pattern without changing its position, assuring a robust developmental process. We also study transient dynamics that shows shift of domain boundary, agreeing with experimental observations. Importance of mutual repression is addressed by comparing with other types of regulations.
机译：发育过程的基因调控网络包含两个基因之间的许多相互抑制的相互作用。它们通常受构成额外的网络主题（称为“调节和调节互环”）的调节或调节。我们对果蝇果蝇基因调控网络的数据库分析表明，具有相互抑制作用的果蝇专门用于细分过程。为了阐明它们的生物学作用，我们在数学上研究了带有相互抑制作用的受控相互循环对输入刺激的响应。我们显示，只要网络输出对于给定的输入水平而言是唯一的，则相互抑制会增加响应灵敏度，而不会影响阈值输入水平以激活目标基因表达。母题的这种高灵敏度可以有助于在不改变其位置的情况下锐化空间域图案，从而确保稳健的显影过程。我们还研究了表明域边界移动的瞬态动力学，与实验观察结果一致。通过与其他类型的法规进行比较，可以解决相互压制的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号