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首页> 外文期刊>Journal of toxicology and environmental health, Part A >Gavage administration of the fungal toxin fumonisin B1 to female Sprague-Dawley rats.
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Gavage administration of the fungal toxin fumonisin B1 to female Sprague-Dawley rats.

机译：对雌性Sprague-Dawley大鼠强饲法给予真菌毒素伏马毒素B1。

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摘要

The fungal toxin fumonisin B1 (FB1) is a contaminant of corn-based foods and feeds produced by members of the genus Fusarium. Fumonisin B1 toxicity was examined using gavage administration of purified toxin to female Sprague-Dawley rats. For 11 consecutive days each rat received a single dose of FB1 at the following concentrations: control (saline), 1, 5, 15, 35, or 75 mg FB1/kg body weight/d. Significantly depressed body weight and food consumption occurred at 35 and 75 mg FB1/kg/d. By the end of the dosing period there were no significant changes in food consumption. Kidneys and bone marrow were most sensitive to FB1 exposure. Changes in renal morphology were observed from 5 to 75 mg FB1/kg/d, accompanied by transient changes in urine osmolality and urine enzyme levels. Increased cellular vacuolation was the primary change associated with bone-marrow toxicity, starting at doses of 5 mg FB1/kg/d. Hepatotoxicity was indicated by reduced liver weight, elevated serum alanine amonitransferase (ALT), and mild histopathological changes occurring at doses of 15 mg FB1/kg/d and higher. Increased cytoplasmic vacuolation of adrenal cortex cells occurred in rats treated with 15 mg FB1/kg/d and higher, indicating that the adrenals are also potential targets of FB1. Elevated serum cholesterol, which is a consistent response to FB1 was observed at 5 mg FB1/kg/d and higher. Based on responses in this study, gavage is an appropriate substitute for longer feeding studies. Compared to previous work with male rats, gender-related difference in FB1 responses lacked consistency but indicated that males may be marginally more sensitive than female Sprague-Dawley rats.
机译：真菌毒素伏马毒素B1（FB1）是镰刀菌属成员生产的玉米类食品和饲料的污染物。通过强饲法向雌性Sprague-Dawley大鼠给药伏马毒素B1毒性。每只大鼠连续11天接受以下剂量的FB1单剂量：对照（盐水），1、5、15、15、35或75 mg FB1 / kg体重/ d。 35和75 mg FB1 / kg / d时，体重和食物消耗显着降低。到给药期结束时，食物消耗没有显着变化。肾脏和骨髓对FB1暴露最敏感。肾形态学变化从5 mg FB1 / kg / d降至75 mg / kg / d，并伴随着尿渗透压和尿酶水平的短暂变化。从5 mg FB1 / kg / d的剂量开始，细胞空泡增加是与骨髓毒性有关的主要变化。肝毒性由肝脏重量减少，血清丙氨酸氨基转移酶（ALT）升高和在15 mg FB1 / kg / d和更高剂量下发生的轻度组织病理学改变指示。用15 mg FB1 / kg / d和更高剂量治疗的大鼠中，肾上腺皮质细胞的胞质空泡增加，这表明肾上腺也是FB1的潜在靶标。在5 mg FB1 / kg / d和更高剂量下观察到血清胆固醇升高，这是对FB1的一致反应。根据本研究的反应，管饲法可以替代较长的喂食研究。与以前的雄性大鼠相比，FB1反应中性别相关的差异缺乏一致性，但表明雄性比雌性Sprague-Dawley大鼠的敏感性略高。

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