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首页> 外文期刊>Journal of toxicology-Clinical toxicology >Fatal cardiovascular collapse following acute colchicine ingestion.
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Fatal cardiovascular collapse following acute colchicine ingestion.

机译:急性秋水仙碱摄入后致命的心血管衰竭。

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BACKGROUND: A previously published prognostic rule predicts 100% survival after ingestion of cochicine doses less than 0.5 mg/kg and 100% mortality after ingestion of more than 0.8 mg/kg. This rule inaccurately predicted survival in a recent case. CASE REPORT: We present a case of fatal colchicine poisoning in an adult who ingested a maximum of 39.6 mg of colchicine (0.40 mg/kg). He subsequently developed hypotension which was refractory to fluid resuscitation and infusion of vasopressors. He died of cardiovascular collapse approximately 35 hours after ingestion. DISCUSSION: Fatal outcomes are possible even with colchicine doses less than 0.5 mg/kg. Physicians caring for colchicine-poisoned patients must be prepared for the possibility of acute cardiovascular collapse and ventricular dysrhythmias regardless of the reported dose of colchicine.
机译:背景:先前发表的预后规则预测,摄入秋水仙碱剂量小于0.5 mg / kg后100%存活,摄入大于0.8 mg / kg死亡率100%。该规则在最近的病例中不准确地预测了存活率。病例报告:我们介绍了一例致命秋水仙碱中毒的成年人,该成年人摄入最多39.6毫克秋水仙碱(0.40毫克/千克)。随后,他发展了低血压,这种低血压难以进行液体复苏和输注血管加压药。摄入后约35小时,他死于心血管衰竭。讨论:即使秋水仙碱剂量小于0.5 mg / kg,也可能导致致命的后果。无论是否报道了秋水仙碱的剂量,都必须为照顾秋水仙碱中毒的患者做好准备,以防止可能发生的急性心血管衰竭和心律不齐。

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