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首页> 外文期刊>Journal of toxicology-Clinical toxicology >Acute chlorpyrifos poisoning in pregnancy: A case report
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Acute chlorpyrifos poisoning in pregnancy: A case report

机译：孕妇急性毒死rif中毒一例

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Background. Pesticide exposures and poisoning are common and generally under-reported in poorly resourced countries where women are mainly involved in agricultural work. Cases of organophosphate poisoning in pregnancy are unusual. Case report. A 22-year-old woman in her 29th week of pregnancy presented to King Edward VIII Hospital, Durban, South Africa having had multiple generalized tonic-clonic seizures at home. An initial presumptive diagnosis of eclampsia was made and treatment using intravenous MgSO_4 was initiated. Signs of OP toxicity included a garlic odor; vomiting, diarrhea, fecal incontinence; hypersecretions with airway compromise, diffuse rhonchi; pinpoint pupils; and muscle weakness and fasciculations. The patient responded to intravenous doses of atropine; oximes were not available. Although the mother survived, the infant was born prematurely and died two days after birth without showing any OP signs. Conclusions. Organophosphate poisoning may mimic acute complications in pregnancy, such as eclampsia and seizures. Immediate management includes general supportive measures and use of specific pharmacological agents such as atropine and oximes. Poisoning during pregnancy may result in serious adverse effects for both mother and the fetus or neonate. Prompt diagnosis and treatment are necessary to avoid adverse outcomes.
机译：背景。在妇女主要从事农业工作的资源贫乏的国家中，农药暴露和中毒现象普遍存在，且普遍被低估。怀孕时有机磷中毒的情况不常见。案例报告。一名22岁妇女在怀孕29周时就诊于南非德班的爱德华八世国王医院，在家中多次发生全身性强直阵挛性癫痫发作。初步推测为先兆子痫，并开始使用静脉内的MgSO_4治疗。 OP毒性的迹象包括大蒜味。呕吐，腹泻，大便失禁;分泌物过多并伴有气道受损，弥散性罗氏菌;查明学生;和肌肉无力和迷恋。患者对阿托品的静脉注射剂量有反应;没有肟。尽管母亲存活下来，但婴儿早产，出生后两天死亡，没有任何OP征象。结论。有机磷中毒可模仿妊娠中的急性并发症，例如子痫和癫痫发作。立即管理包括一般的支持措施和使用特定的药物，如阿托品和肟。怀孕期间中毒可能会对母亲和胎儿或新生儿造成严重的不良影响。及时诊断和治疗对于避免不良后果是必要的。

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