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首页> 外文期刊>Journal of Veterinary Diagnostic Investigation >Hepatitis and enteritis caused by a novel herpesvirus in two monitor lizards (Varanus spp.).
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Hepatitis and enteritis caused by a novel herpesvirus in two monitor lizards (Varanus spp.).

机译：在两个监控蜥蜴（ Varanus spp。）中由新型疱疹病毒引起的肝炎和肠炎。

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摘要

Reported cases of herpesvirus-induced disease are uncommon in most species of reptiles, with the majority of reports in chelonians. Two monitor lizards (Varanus spp.) presented for postmortem examination at the Veterinary Medical Diagnostic Laboratory at the University of Missouri. Tan, 1-2-mm foci were grossly visible on the mucosal surface of the intestine and in the liver. Microscopically, there was multifocal necrosis in the lamina propria of the small intestine and in the liver. Many of the degenerate cells contained large, eosinophilic intranuclear inclusions. Enveloped icosahedral virions consistent with herpesvirus were detected by electron microscopy. A 180-bp DNA fragment was amplified by polymerase chain reaction from samples of small intestine and liver using primers that targeted a portion of the herpesvirus DNA polymerase gene. The sequence of the fragment was determined to be most closely related to Varanid herpesvirus 2 (80% nucleotide identity, 82% amino acid identity). Based on histological and molecular findings, a novel pathogenic herpesvirus of lizards in the family Varanidae is proposed.
机译：在大多数爬行动物中，疱疹病毒引起的疾病的报告病例并不多见，大多数报告是在凯隆犬中进行的。在密苏里州大学的兽医诊断实验室提交了两只监控蜥蜴（ Varanus spp。）进行死后检查。在肠粘膜表面和肝脏中可见到棕褐色的1-2-mm病灶。镜下可见，小肠固有层和肝脏多灶性坏死。许多简并细胞含有大的嗜酸性核内包裹体。通过电子显微镜检测到与疱疹病毒一致的包裹的二十面体病毒体。使用针对疱疹病毒DNA聚合酶基因一部分的引物，通过聚合酶链反应从小肠和肝脏样品中扩增出180 bp的DNA片段。确定该片段的序列与瓦拉尼德疱疹病毒2最密切相关（80％的核苷酸同一性，82％的氨基酸同一性）。基于组织学和分子学发现，提出了一种新的蜥蜴致病性疱疹病毒。

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