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首页> 外文期刊>Journal of voice: official journal of the Voice Foundation >In Vivo engineering of the vocal fold ECM with injectable HA hydrogels-late effects on tissue repair and biomechanics in a rabbit model.
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In Vivo engineering of the vocal fold ECM with injectable HA hydrogels-late effects on tissue repair and biomechanics in a rabbit model.

机译：体内注射声带ECM的工程设计，具有可注射的HA水凝胶对兔子模型中的组织修复和生物力学的影响。

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OBJECTIVES: To determine if the utilization of injectable chemically modified hyaluronan (HA) derivative at the time of intentional vocal fold resection may facilitate wound repair and preserve the unique viscoelastic properties of the extracellular matrix (ECM) and lamina propria 6 months after treatment. STUDY DESIGN: Prospective, controlled animal study. METHODS: Twelve rabbit vocal folds were biopsied bilaterally, and the left side of vocal fold was treated with Extracel, an injectable, chemically modified HA derivative, and the right side of vocal fold was injected with saline as control at the time of resection. Animals were sacrificed 6 months after biopsy and injection. Outcomes measured include transcription levels for procollagen, fibronectin, fibromodulin, transforming growth factor beta one (TGF-beta1), HA synthase, and hyaluronidase, and tissue biomechanics-viscosity and elasticity. RESULTS: Extracel-treated vocal folds were found to have significantly less fibrosis than saline-treated controls. Extracel-treated vocal folds had significantly improved biomechanical properties of elasticity and viscosity. Significantly decreased levels of fibronectin, fibromodulin, TGF-beta1, procollagen I, and HA synthase were measured. CONCLUSIONS: Prophylactic in vivo manipulation of the ECM with an injectable HA hydrogel appears to induce vocal fold tissue regeneration to yield improved tissue composition and biomechanical properties at 6 months.
机译：目的：确定在有意进行声带切除时是否使用可注射的化学修饰的透明质酸（HA）衍生物可促进伤口修复并在治疗后6个月保留细胞外基质（ECM）和固有层的独特粘弹性。研究设计：前瞻性对照动物研究。方法：对十二个兔子的声带进行双侧活检，声带的左侧用Extracel处理，注射剂经过化学修饰的HA衍生物，在声带的右侧注射生理盐水作为对照。在活检和注射后6个月处死动物。测得的结果包括胶原蛋白，纤连蛋白，纤维调节蛋白，转化生长因子β1（TGF-beta1），HA合酶和透明质酸酶的转录水平，以及组织生物力学的粘度和弹性。结果：与生理盐水对照组相比，经Extracel处理的声带纤维化明显减少。 Extracel处理的声带具有显着改善的弹性和粘性生物力学性能。纤连蛋白，纤维调节蛋白，TGF-β1，前胶原I和HA合酶的水平显着下降。结论：用可注射的HA水凝胶对ECM进行预防性体内操作似乎可以诱导声带组织再生，从而在6个月时产生改善的组织组成和生物力学特性。

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