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首页> 外文期刊>Journal of trace elements in medicine and biology: Organ of the Society for Minerals and Trace Elements (GMS) >Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon
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Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon

机译：硒对二嗪农暴露大鼠脂质过氧化，高脂血症及生化指标的抗氧化作用

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摘要

Diazinon (DZN) is one of the most organophosphate insecticides that widely used in agriculture and industry. Selenium is generally recognized to be a trace mineral of great importance for human health, protecting the cells from the harmful effects of free radicals. Therefore, the present study was carried out to investigate the alterations in biochemical parameters, free radicals and enzyme activities induced by diazinon in male rat serum, and the role of selenium in alleviating the negative effects of DZN. Animals were divided into four groups of seven rats each; the first group was used as control. Groups 2, 3 and 4 were treated with selenium (Se; 200. μg/kg BW), diazinon (DZN; 10. mg/kg BW) and diazinon plus selenium, respectively. Rats were orally administered their respective doses daily for 30 days. Results obtained showed that DZN significantly induced thiobarbituric acid reactive substances (TBARS) and decreased the activities of glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) and the levels of reduced glutathione (GSH) in rat sera. Aminotransferases (AST, ALT), phosphatases (AlP, AcP) and lactate dehydrogenase (LDH) activities were significantly increased while acetylcholinesterase (AChE) activity was decreased due to DZN administration. Also, DZN treatment caused significant perturbations in lipids profile and serum biochemical parameters. On the other hand, Se alone significantly decreased the levels of TBARS, total lipids, cholesterol, urea and creatinine, while increased the activities of antioxidant enzymes and glutathione content, total protein (TP) and albumin. In addition, Se in combination with DZN partially or totally alleviated its toxic effects on the studied parameters. In conclusion, Se has beneficial effects and could be able to antagonize DZN toxicity.
机译：二嗪农（DZN）是在农业和工业中广泛使用的最有机磷杀虫剂之一。硒被普遍认为是对人体健康至关重要的微量矿物质，可保护细胞免受自由基的有害影响。因此，本研究旨在研究二嗪农在雄性大鼠血清中引起的生化参数，自由基和酶活性的变化，以及硒在减轻DZN负作用中的作用。将动物分为四组，每组七只大鼠。第一组用作对照。第2、3和4组分别用硒（Se; 200.μg/ kg BW），二嗪农（DZN; 10. mg / kg BW）和二嗪农加硒处理。每天给大鼠口服各自的剂量，持续30天。结果表明，DZN显着诱导了硫代巴比妥酸反应性物质（TBARS），并降低了谷胱甘肽S-转移酶（GST），超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx）和谷胱甘肽还原酶（GR）的活性，大鼠血清中谷胱甘肽（GSH）的水平降低。施用DZN后，氨基转移酶（AST，ALT），磷酸酶（AlP，AcP）和乳酸脱氢酶（LDH）活性显着增加，而乙酰胆碱酯酶（AChE）活性降低。同样，DZN处理引起脂质分布和血清生化参数的显着扰动。另一方面，仅硒会显着降低TBARS，总脂质，胆固醇，尿素和肌酐的水平，同时会增加抗氧化酶的活性以及谷胱甘肽含量，总蛋白（TP）和白蛋白。此外，硒与DZN的结合部分或全部减轻了其对研究参数的毒性作用。总之，硒具有有益的作用，并且可以拮抗DZN毒性。

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