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首页> 外文期刊>Journal of vascular research >Distribution and peptide content of sympathetic axons innervating different regions of the cutaneous venous bed in the pinna of the guinea pig ear.
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Distribution and peptide content of sympathetic axons innervating different regions of the cutaneous venous bed in the pinna of the guinea pig ear.

机译：分布在豚鼠耳廓皮静脉床不同区域的交感神经轴突的分布和肽含量。

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This study utilised catecholamine fluorescence histochemistry, multiple-labelling immunohistochemistry and retrograde axonal transport to determine the distribution and neuropeptide content of sympathetic neurons innervating veins in the dorsal skin of the guinea pig pinna. There was a dense plexus of sympathetic axons innervating the large central vein at the base of the ear and the adjoining maxillary vein. The density of the plexus decreased towards the distal margin of the ear and in smaller veins, and was very sparse in the lateral veins at the base of the ear. Small venules < 50-80 microns diameter were not innervated. Probably all noradrenergic axons in the large veins near the base of the ear contained immunoreactivity (IR) to neuropeptide Y (NPY), but the proportion of axons with NPY-IR decreased in large veins in more lateral regions of the ear, and in smaller veins (80-100 microns diameter). Injections of Fast Blue or DiI close to large veins in the ear resulted in retrograde labelling of tyrosine hydroxylase-IR neurons in the ipsilateral superior cervical ganglion, 64% of which contained NPY-IR. Nearly all (> 90%) of the TH-IR axons in small and large veins also contained IR to dynorphin-related peptides. Thus, sympathetic venoconstriction in the thermoregulatory bed of the guinea pig pinna is likely to occur predominantly in the large central veins towards the base of the ear. Furthermore, sympathetic constriction is likely to be qualitatively different in large cutaneous veins from that occurring in small veins, and absent altogether from small venules and some lateral veins.
机译：这项研究利用儿茶酚胺荧光组织化学，多标记免疫组化和逆行轴突运输来确定豚鼠耳廓背神经支配静脉中交感神经元的分布和神经肽含量。交感神经轴突有一个密集的神经丛，支配着耳朵底部的大中央静脉和相邻的上颌静脉。丛的密度朝着耳朵的远侧边缘和较小的静脉减少，而在耳根的侧静脉非常稀疏。直径小于50-80微米的小静脉没有被神经支配。靠近耳朵根部的大静脉中的所有去甲肾上腺素能轴突均含有对神经肽Y（NPY）的免疫反应（IR），但在耳朵的更多侧部和较小的大静脉中，带有NPY-IR的轴突的比例下降静脉（直径80-100微米）。在耳朵附近大静脉附近注射快速固蓝或DiI导致同侧上颈神经节中酪氨酸羟化酶-IR神经元的逆行标记，其中64％包含NPY-IR。大小静脉中几乎所有（> 90％）的TH-1R轴突也都含有强啡肽相关肽的IR。因此，豚鼠耳廓温度调节床上的交感性静脉收缩很可能主要发生在朝向耳朵根部的大中央静脉中。此外，交感性收缩在大的皮肤静脉中与在小静脉中发生的同质收缩可能在质量上有所不同，而在小静脉和一些侧静脉中完全没有。

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