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首页> 外文期刊>Journal of trace elements in medicine and biology: Organ of the Society for Minerals and Trace Elements (GMS) >Antibacterial and ulcer healing effects of organoselenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model.
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Antibacterial and ulcer healing effects of organoselenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model.

机译：有机硒化合物在萘普生诱导和幽门螺杆菌感染的Wistar大鼠模型中的抗菌和溃疡愈合作用。

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Aim of the present study was to evaluate in vitro toxicity and in vivo antibacterial, anti-inflammatory, antiulcer, and antioxidant activities of two organoselenium compounds, selenocystine (SeCys) and ebselen (Ebs). The study was conducted in experimentally induced ulcers in rodent model infected with Helicobacter pylori (H. pylori). In vitro toxicological studies on normal splenic lymphocytes revealed that SeCys and Ebs were non-toxic to the cells even at 100 muM concentration. Antibacterial activity was observed at 500 mug/mL concentration of either of the compounds against H. pylori. In vivo studies after treatment with SeCys and Ebs (500 mug/kg/day) resulted in significant reduction in ROS production and inhibition of lipid peroxidation in gastric tissue. The antioxidant and anti-inflammatory activities of both the compounds were also confirmed by their ability to lower GSH reduction, to induce the expression of antioxidant genes such as GPx-4, and MnSOD and to suppress inflammatory genes namely COX-2, TNF-alpha and TGF-beta. In addition, the immunomodulatory activity of both the compounds was evident by enhance of the CD4 levels and maintenance of the IgG, IL-6 and IL-10 levels. Persistent treatment (500 mug/kg, for 28 days) with both the compounds showed considerable (p<0.05) ulcer healing property supporting its role in gastro protection. In conclusion, the results of our study suggest that both SeCys and Ebs possess broad spectrum of activities without any potential toxicity.
机译：本研究的目的是评估两种有机硒化合物硒代半胱氨酸（SeCys）和依布硒仑（Ebs）的体外毒性以及体内抗菌，抗炎，抗溃疡和抗氧化活性。该研究是在感染幽门螺杆菌（H. pylori）的啮齿动物模型中的实验性溃疡中进行的。对正常脾脏淋巴细胞的体外毒理学研究表明，即使浓度为100μM，SeCys和Ebs对细胞也无毒。两种化合物在500杯/毫升的浓度下均观察到针对幽门螺杆菌的抗菌活性。用SeCys和Ebs（500杯/千克/天）治疗后的体内研究导致ROS产生显着减少，并抑制了胃组织中的脂质过氧化。两种化合物的抗氧化和抗炎活性还通过降低GSH还原，诱导抗氧化基因（如GPx-4和MnSOD）的表达以及抑制炎症基因（即COX-2，TNF-α）的能力得到证实。和TGF-beta。另外，两种化合物的免疫调节活性通过CD4水平的增强和IgG，IL-6和IL-10水平的维持而明显。两种化合物的持久治疗（500杯/千克，持续28天）均显示出可观的（p <0.05）溃疡愈合特性，支持了其在胃保护中的作用。总之，我们的研究结果表明，SeCys和Ebs都具有广泛的活性谱，没有任何潜在的毒性。

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