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首页> 外文期刊>Communications in Agricultural and Applied Biological Sciences >Side-effects of fenazaquin on a cellular model of Paramecium.
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Side-effects of fenazaquin on a cellular model of Paramecium.

机译：Fenazaquin对草履虫细胞模型的副作用。

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摘要

Our biodiversity has long been preserved, but the main constituents of our environment have been particularly affected by the addition of molecules resulting from agricultural and industrial activities. It is well accepted that these changes may stress some species, making them more vulnerable. In this project, we determined the disruptive side-effects of a pesticide on several biochemical endpoints and the behaviour of a microorganism as the ciliate protist Paramecium sp. Here we used fenazaquin [4-(4-tert-butylphenethoxy)quinazoline] that belongs to the quinazoline class of chemicals and that is a pesticide intended to control mites and insects; its route of exposure is ingestion and dermal, and its mode of action is the disruption of the biochemistry of insect mitochondria. In our experiments with fenazaquin at 40, 60 and 80 nM, we recorded disturbances in protein and glutathione, in glutathione S-transferase, and a decrease in consumption of oxygen. The results are discussed in relation to potential risks and mechanisms of action. In addition, the data can be used as reference values in further testing with other pesticides and chemistries.
机译：我们的生物多样性一直得到保存，但是我们环境的主要组成部分特别受到了农业和工业活动产生的分子的影响。这些变化可能会对某些物种造成压力，这使它们更加脆弱，这已为人们所公认。在这个项目中，我们确定了农药在几个生化终点上的破坏性副作用以及作为纤毛虫原虫Paramecium sp。的微生物的行为。在这里，我们使用了氟氮杂喹[4-（4-叔丁基苯乙氧基）喹唑啉]，它属于喹唑啉类化学品，是一种旨在防治螨虫和昆虫的农药。它的接触途径是摄入和皮肤接触，其作用方式是破坏昆虫线粒体的生物化学。在使用40、60和80 nM的Fenazaquin进行的实验中，我们记录了蛋白质和谷胱甘肽，谷胱甘肽S-转移酶的紊乱以及氧气消耗的减少。讨论了有关潜在风险和作用机制的结果。此外，这些数据可以用作其他农药和化学药品的进一步测试的参考值。

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