...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Virological Methods >Use of hepatitis E IgG avidity for diagnosis of hepatitis E infection
【24h】

Use of hepatitis E IgG avidity for diagnosis of hepatitis E infection

机译：戊型肝炎IgG抗体在诊断戊型肝炎中的应用

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The diagnosis of acute hepatitis E infection is based on the detection of HEV RNA or specific IgM in immunocompetent patients. Viraemia and excretion of HEV RNA in faeces are not observed in all patients and commercial kits vary in their performance for anti-HEV IgM detection. Additional diagnostic tests must therefore be considered. The value of anti-HEV IgG avidity index for differentiating between acute infection and previous exposure to REV in countries of low endemicity was investigated. 132 specimens were included, with 39 serum samples from patients with known H EV infection, studied retrospectively. IgG avidity index was high (>60%) in patients with previous infection (n = 16) or polyclonal activation (n = 3) but was low (<40%) in patients with acute infection (n = 20). Then, 93 serum samples from patients, checking for acute hepatitis (detection of anti-HEV IgM but not of HEV RNA) were investigated. IgG avidity index was <40% in 77 of these patients, consistent with acute infection. It exceeded 60% in 15 patients, providing evidence of contact with HEV up to six months previously. One patient had an uninterpretable biological profile, with an IgG avidity index between 40% and 60%. IgG mature slowly during HEV infection, over a period of six months. IgG avidity index can therefore be used to exclude primary infection. This method should improve the diagnosis of acute hepatitis E.
机译：急性戊型肝炎感染的诊断基于对具有免疫功能的患者的HEV RNA或特异性IgM的检测。在所有患者中均未观察到粪便中病毒血症和HEV RNA的排泄，市售试剂盒检测抗HEV IgM的性能各不相同。因此，必须考虑其他诊断测试。研究了抗-HEV IgG亲和力指数在低流行国家中区分急性感染和先前接触REV的价值。回顾性研究了132个样本，并从已知的H EV感染患者中提取了39个血清样本。既往感染（n = 16）或多克隆激活（n = 3）患者的IgG亲和力指数高（> 60％），而在急性感染（n = 20）的患者中IgG亲和力指数低（<40％）。然后，对来自患者的93份血清样本进行了检查，以检查是否患有急性肝炎（检测到抗HEV IgM，但未检测到HEV RNA）。这些患者中有77名患者的IgG亲和力指数<40％，与急性感染相符。 15名患者中超过60％，提供了直到六个月前接触过HEV的证据。一名患者的生物学特征无法解释，IgG亲和力指数在40％至60％之间。 IgG在HEV感染期间缓慢成熟，持续六个月。因此，IgG亲和力指数可用于排除原发感染。此方法应改善急性戊型肝炎的诊断。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号