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首页> 外文期刊>Communications in Agricultural and Applied Biological Sciences >IN VITRO CHARACTERIZATION OF GASTROINTESTINAL BEHAVIOR OF BUTYRICICOCCUS PULLICAECORUM, A NOVEL BUTYRATE PRODUCING ISOLATE WITH PROBIOTIC POTENTIAL TO COUNTERBALANCE DYSBIOSIS IN INFLAMMATORY BOWEL DISEASE
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IN VITRO CHARACTERIZATION OF GASTROINTESTINAL BEHAVIOR OF BUTYRICICOCCUS PULLICAECORUM, A NOVEL BUTYRATE PRODUCING ISOLATE WITH PROBIOTIC POTENTIAL TO COUNTERBALANCE DYSBIOSIS IN INFLAMMATORY BOWEL DISEASE

机译：牛肝菌胃肠道行为的体外表征，一种新型的产生酸的布丁酸盐，对肠炎性肠病的平衡性不良反应有可能发生。

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摘要

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract, which leads to abdominal cramping and bloody diarrhea. The population of IBD patients grows every year worldwide (Molodecky et al, 2012).The exact trigger for the onset of the disease is still unclear but there is a well-established link between the gut bacteria and inflammation. IBD patients have both on phylogenetic as on functional level an unbalanced gut microbiota (Frank et al, 2007;Sokol et al, 2006). Therefore, manipulation of this unbalanced microbial community is an attractive therapeutic strategy. Butyrate is one of the metabolites produced by human gut microbes during carbohydrate fermentation. It has well-described beneficial effects in IBD, but the delivery into the gut is problematic. Administration of butyrate-producing bacteria that are able to colonize the gut is therefore a possible solution for the delivery problem (Van Immerseel et al, 2010).
机译：炎症性肠病（IBD）的特征是胃肠道的慢性炎症，导致腹部绞痛和血性腹泻。 IBD患者的数量每年在全球范围内增长（Molodecky et al，2012）。目前尚不清楚该病发作的确切诱因，但肠道细菌与炎症之间存在着公认的联系。 IBD患者在系统发育和功能水平上均具有不平衡的肠道菌群（Frank等，2007; Sokol等，2006）。因此，操纵这种不平衡的微生物群落是一种有吸引力的治疗策略。丁酸盐是人类肠道微生物在碳水化合物发酵过程中产生的代谢产物之一。它在IBD中具有众所周知的有益作用，但是将其递送至肠道是有问题的。因此，能够在肠道内定殖的产生丁酸盐的细菌的给药是解决输送问题的一种可能的解决方案（Van Immerseel等，2010）。

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