Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus.

Camuzcuoglu H; Toy H; Cakir H; Celik H; Erel O

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Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus.

机译：妊娠糖尿病妇女未来动脉粥样硬化性心脏病的发病机理中对氧磷酶和芳基酯酶活性的降低。

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OBJECTIVE: The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM). METHODS: Paraoxonase and arylesterase activities, and LOOH levels were assessed for GDM cases (n = 55) and controls (n = 59). Serum basal and salt-stimulated paraoxonase and arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. RESULTS: Basal and salt-stimulated paraoxonase and arylesterase activities were significantly lower (p = 0.002, p = 0.004; and p = 0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p < 0.001). Among gestational diabetes patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = - 0.390, p = 0.003; and r = - 0.287, p = 0.034, respectively). CONCLUSIONS: Findings of the present study have shown that serum paraoxonase and arylesterase activities are significantly reduced in women with GDM. Decreased serum paraoxonase and arylesterase activities might play a role in the potential early pathogenesis for atherosclerotic heart disease in GDM beyond their antioxidant properties.

机译：目的：本研究旨在调查妊娠糖尿病（GDM）患者的血清对氧磷酶，芳基酯酶活性和脂质过氧化氢（LOOH）水平。方法：对GDM患者（n = 55）和对照组（n = 59）评估了对氧磷酶和芳基酯酶的活性以及LOOH水平。分光光度法测定血清基础和盐刺激的对氧磷酶和芳基酯酶的活性。通过二甲酚橙测定法通过亚铁氧化来测量LOOH水平。结果：与对照组相比，GDM患者的基础和盐刺激的对氧磷酶和芳基酯酶活性显着降低（分别为p = 0.002，p = 0.004和p = 0.013），而LOOH水平则明显升高（p <0.001）。在妊娠糖尿病患者中，血清对氧磷酶和芳基酯酶活性与LOOH水平呈负相关（r =-0.390，p = 0.003; r =-0.287，p = 0.034）。结论：本研究的结果表明，GDM妇女的血清对氧磷酶和芳基酯酶活性明显降低。血清对氧磷酶和芳基酯酶活性的降低可能会在GDM的动脉粥样硬化性心脏病的潜在早期发病机理中发挥作用，其抗氧化特性超出其范围。

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《Journal of women’s health》 |2009年第9期|共5页
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Camuzcuoglu H; Toy H; Cakir H; Celik H; Erel O;
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1. Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus. [J] . Camuzcuoglu H, Toy H, Cakir H, Journal of women’s health . 2009,第9期

机译：妊娠糖尿病妇女未来动脉粥样硬化性心脏病的发病机理中对氧磷酶和芳基酯酶活性的降低。
2. Sex differences in the pathogenesis of type 2 diabetes may explain the stronger impact of diabetes on atherosclerotic heart disease in women [J] . Mauvais-Jarvis Franck Journal of diabetes and its complications . 2019,第6期

机译：2型糖尿病发病机制的性差异可以解释糖尿病对女性动脉粥样硬化心脏病的更强烈影响
3. Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? [J] . Dursun P, Demirtas E, Bayrak A, Human Reproduction . 2006,第1期

机译：血清对氧磷酶1（PON1）活性降低：PCOS患者动脉粥样硬化性心脏病的另一个危险因素？
4. Joint Effects of Phthalate Exposure and Serum Paraoxonase (PON1) Activity on Estrogen-dependent Diseases in Taiwanese Women [C] . Meng-Chu Chung, Shu-Li Wang, Eng-Mei Tsai, International symposium on halogenated persistent organic pollutants . 2009

机译：邻苯二甲酸酯暴露和血清对氧磷酶（PON1）活性对台湾女性雌激素依赖性疾病的联合影响
5. Daily Walking Is Effective for Management of Pregnant Women with Gestational Diabetes Mellitus. [D] . Hayashi, Ayako 2019

机译：每日步行对妊娠糖尿病孕妇的治疗有效。
6. Evaluation of Paraoxonase Arylesterase and Homocysteine Thiolactonase Activities in Patients with Diabetes and Incipient Diabetes Nephropathy [O] . Durmuş Ayan, Mehmet Şeneş, Ayşe Banu Çaycı, 2019

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Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus.

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