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首页> 外文期刊>Journal of women’s health >Red versus white wine as a nutritional aromatase inhibitor in premenopausal women: A pilot study
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Red versus white wine as a nutritional aromatase inhibitor in premenopausal women: A pilot study

机译：红酒与白葡萄酒作为绝经前女性的营养性芳香酶抑制剂：一项初步研究

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Background: An increased risk of breast cancer is associated with alcohol consumption; however, it is controversial whether red wine increases this risk. Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogen and occur naturally in grapes, grape juice, and red, but not white wine. We tested whether red wine is a nutritional AI in premenopausal women. Methods: In a cross-over design, 36 women (mean age [SD], 36 [8] years) were assigned to 8 ounces (237 mL) of red wine daily then white wine for 1 month each, or the reverse. Blood was collected twice during the menstrual cycle for measurement of estradiol (E2), estrone (E1), androstenedione (A), total and free testosterone (T), sex hormone binding globulin (SHBG), luteinizing hormone (LH), and follicle stimulating hormone (FSH). Results: Red wine demonstrated higher free T vs. white wine (mean difference 0.64 pg/mL [0.2 SE], p=0.009) and lower SHBG (mean difference -5.0 nmol/L [1.9 SE], p=0.007). E2 levels were lower in red vs. white wine but not statistically significant. LH was significantly higher in red vs. white wine (mean difference 2.3 mIU/mL [1.3 SE], p=0.027); however, FSH was not. Conclusion: Red wine is associated with significantly higher free T and lower SHBG levels, as well as a significant higher LH level vs. white wine in healthy premenopausal women. These data suggest that red wine is a nutritional AI and may explain the observation that red wine does not appear to increase breast cancer risk.
机译：背景：饮酒会增加患乳腺癌的风险;但是，红酒是否会增加这种风险还存在争议。芳香酶抑制剂（AIs）可以防止雄激素转化为雌激素，并且天然存在于葡萄，葡萄汁和红葡萄酒中，而白葡萄酒中则没有。我们测试了绝经前女性中红酒是否是一种营养性AI。方法：采用交叉设计，每天将36例女性（平均年龄[SD]，36 [8]岁）分配给8盎司（237毫升）的红酒，然后分配给白葡萄酒，每个月1个月，或相反。在月经周期中采集两次血液，用于测量雌二醇（E2），雌酮（E1），雄烯二酮（A），总睾丸激素和游离睾丸激素（T），性激素结合球蛋白（SHBG），黄体生成激素（LH）和卵泡刺激性激素（FSH）。结果：红酒与白葡萄酒相比，游离T值更高（平均差异0.64 pg / mL [0.2 SE]，p = 0.009），SHBG更低（平均差异-5.0 nmol / L [1.9 SE]，p = 0.007）。红葡萄酒中的E2水平低于白葡萄酒，但无统计学意义。红葡萄酒中的LH明显高于白葡萄酒（平均差异2.3 mIU / mL [1.3 SE]，p = 0.027）;但是，FSH不是。结论：与健康绝经前女性相比，红酒与白葡萄酒的游离T含量明显升高和SHBG含量降低以及LH含量显着升高相关。这些数据表明，红酒是一种营养性AI，并且可能解释了红酒似乎不会增加患乳腺癌风险的观察结果。

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