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首页> 外文期刊>Journal of women’s health >Signs and symptoms of suspected myocardial ischemia in women: results from the What is the Optimal Method for Ischemia Evaluation in WomeN? Trial.
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Signs and symptoms of suspected myocardial ischemia in women: results from the What is the Optimal Method for Ischemia Evaluation in WomeN? Trial.

机译：女性可疑心肌缺血的体征和症状：来自WomeN的最佳缺血评估方法是什么？试用。

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BACKGROUND: Much of our understanding of gender differences in chest pain was derived from noncontemporary reports. The aim of the current report was to compare the frequency of chest pain by measures of ischemia in 824 women with suspected myocardial ischemia prospectively enrolled in a clinical trial of exercise testing with electrocardiography (ETT-ECG) alone compared to myocardial perfusion single photon emission computed tomography (SPECT) (ETT-MPS). METHODS: Women seeking evaluation of chest pain or anginal equivalent symptoms were randomized to ETT-ECG or ETT-MPS with Tc-99m tetrofosmin. The Women's Ischemia Syndrome Evaluation (WISE) and Seattle Angina Questionnaire (SAQ) chest pain and Duke Activity Status Index (DASI) questionnaires were employed in enrolled women. Higher SAQ scores denote improved symptoms or functioning. RESULTS: Eight hundred twenty-four women, average age 63 years, at intermediate-high coronary artery disease (CAD) likelihood were enrolled from 43 North American centers. Traditional cardiac risk factors were prevalent, with nearly half of women having a family history of premature coronary disease, hypertension, and hyperlipidemia. Chest pain symptoms occurring at least one to three times per week were reported in 60% of women. An examination of the SAQ domains revealed that although women reported minimal physical limitations (median, interquartile range [IQR] 88, 75-100), there was a greater frequency of stable chest pain symptoms (median, IQR=40, 30-50). The majority of women (79%) reported moderate to heavy physical activity levels at home, with the average ETT and DASI estimated metabolic equivalents (METs) of 8.6+/-2.6 and 11.5+/-3.8. Women with more frequent daily episodes of chest pain were more likely to have a lower Duke Treadmill Score (DTS), 1 or mm of ST segment depression, and an abnormal MPS. CONCLUSIONS: The current report details a contemporary evaluation of female-specific symptomatology and measures of myocardial ischemia. Women reporting frequent angina were more likely to exhibit ischemia and this may characterize a female-specific typical angina pattern.
机译：背景：我们对胸痛中性别差异的大部分理解来自非当代报道。本报告的目的是通过比较仅通过心电图运动试验（ETT-ECG）进行的一项临床试验的824名怀疑有心肌缺血的妇女通过局部缺血测量的胸痛发生频率，与计算出的心肌灌注单光子发射进行比较断层扫描（SPECT）（ETT-MPS）。方法：将寻求评估胸痛或心绞痛等效症状的妇女随机分为ETT-ECG或ETT-MPS联合Tc-99m trotrofosmin。在入组妇女中使用了妇女缺血综合症评估（WISE）和西雅图心绞痛问卷（SAQ）胸痛和杜克活动状态指数（DASI）问卷。较高的SAQ分数表示症状或功能得到改善。结果：来自北美43个中心的242位平均年龄为63岁的平均高冠状动脉疾病（CAD）的女性入组。传统的心脏危险因素普遍存在，近一半的女性有过早的冠心病，高血压和高脂血症的家族史。据报道60％的女性每周至少发生1至3次胸痛症状。对SAQ域的检查显示，尽管女性报告的身体限制极小（中位数，四分位间距[IQR] 88、75-100），但稳定的胸痛症状发生率较高（中位数，IQR = 40、30-50） 。大多数妇女（79％）报告说在家中有中等强度的体育活动，而ETT和DASI估计的平均代谢当量（METs）分别为8.6 +/- 2.6和11.5 +/- 3.8。每天发生更频繁的胸痛的女性更有可能出现较低的Duke跑步机得分（DTS），ST段压低1毫米或1毫米以及MPS异常。结论：本报告详细描述了当代女性特定症状的评估和心肌缺血的措施。报告频繁型心绞痛的女性更容易出现局部缺血，这可能是女性特有的典型心绞痛的特征。

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