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首页> 外文期刊>Journal of women’s health >Acceptability of vaginal film, soft-gel capsule, and tablet as potential microbicide delivery methods among African women.
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Acceptability of vaginal film, soft-gel capsule, and tablet as potential microbicide delivery methods among African women.

机译：阴道薄膜，软胶囊和片剂在非洲妇女中作为潜在的杀菌剂递送方法的可接受性。

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BACKGROUND: Vaginal microbicides are in development for the prevention of HIV transmission to women via sexual intercourse. Acceptability of the microbicide delivery method in the targeted population is important to product adherence and, therefore, product effectiveness. It is anticipated that multiple delivery methods will be required to satisfy personal preferences among future microbicide users. METHODS: A total of 526 sexually active women aged 18-30 years participated in a consumer product preference study in Burkina Faso, Tanzania, and Zambia. Screened women who had given consent were instructed to use each of the three products (placebo formulations of a vaginal tablet, film, and soft-gel capsule) once daily for 7 consecutive days for a total of 21 days. Women were interviewed about their impressions of the product at the completion of each 7-day trial period. RESULTS: Over 80% of women reported they liked using each dosage form, and over 85% said they would definitely use it. The film and soft-gel capsule were chosen significantly more often than the tablet as the preferred dosage form (39% and 37% vs. 25%, respectively) mainly because of faster dissolving time and easier insertion. Women in Burkina Faso and Tanzania preferred the soft-gel capsule (42%-46%), whereas Zambian women preferred the film (51%). Age, socioeconomic status, and marital status did not significantly affect product preference. CONCLUSIONS: All three dosage forms were acceptable to the women surveyed. Preferred dosage forms varied by country. These data suggest that the availability of microbicides in multiple dosage forms may increase acceptability, adherence, and, therefore, effectiveness.
机译：背景：阴道杀菌剂正在开发中，以防止艾滋病毒通过性交传播给妇女。杀微生物剂递送方法在目标人群中的可接受性对产品依从性和产品有效性至关重要。预期将需要多种递送方法以满足未来杀菌剂使用者的个人喜好。方法：共有526名18-30岁的性活跃妇女参加了布基纳法索，坦桑尼亚和赞比亚的消费品偏好研究。接受过筛查的女性被指示每天使用三种产品（阴道片剂，薄膜和软胶囊的安慰剂），连续7天，共21天。在每个7天的试用期结束时，对女性进行了有关产品印象的访谈。结果：超过80％的女性表示喜欢使用每种剂型，而超过85％的女性表示肯定会使用该剂型。薄膜和软胶囊的选择频率比片剂高得多，分别作为首选剂型（分别为39％和37％比25％），这主要是因为溶解时间更快且易于插入。布基纳法索和坦桑尼亚的女性偏爱软胶囊（42％-46％），而赞比亚女性偏爱软胶囊（51％）。年龄，社会经济状况和婚姻状况并未显着影响产品偏好。结论：所有三种剂型均为接受调查的女性所接受。优选的剂型因国家而异。这些数据表明，多种剂型中杀微生物剂的可用性可提高可接受性，依从性并因此提高有效性。

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