...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of women’s health >Hormonal Contraception and Risk of Psychiatric and Other Noncommunicable Diseases in HIV-Infected Women
【24h】

Hormonal Contraception and Risk of Psychiatric and Other Noncommunicable Diseases in HIV-Infected Women

机译：艾滋病毒感染妇女的激素避孕和精神病及其他非传染性疾病的风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Hormonal contraception use is common among human immunodeficiency virus (HIV)-infected women. Risk of psychiatric and other noninfectious complications of hormonal contraception use has not been described in this population. Methods: We performed a retrospective cohort study of HIV-infected women receiving care in Tennessee from 1998 to 2008 to examine the risks of incident psychiatric and other noncommunicable diseases (NCDs), including cardiovascular, hepatic, renal, and malignant diseases, and hormonal contraception use, including depot medroxyprogesterone acetate (DMPA) and combined estrogen- and progestin-containing hormonal contraceptives. We used marginal structural models with inverse probability weights to account for time-varying confounders associated with hormonal contraception use. Results: Of the 392 women included, 94 (24%) used hormonal contraception during the study period. Baseline psychiatric disease was similar between women who received and did not receive hormonal contraception. There were 69 incident psychiatric diagnoses and 72 NCDs. Only time-varying DMPA use was associated with increased risk of psychiatric disease (adjusted odds ratio [aOR] 3.70; 95% confidence interval [95% CI] 1.32-10.4) and mood disorders, specifically (aOR 4.70 [1.87-11.8]). Time-varying and cumulative combined hormonal contraception use were not statistically associated with other NCDs (aOR 1.64, 95% CI 0.64-4.12 and aOR 1.16, 95% CI 0.86-1.56, respectively). However, risk of incident NCDs was increased with cumulative DMPA exposure (per year exposure aOR 1.45, 95% CI 1.01-2.08). Conclusions: Among HIV-infected women, DMPA was associated with risk of incident psychiatric diseases, particularly mood disorders, during periods of use. Cumulative DMPA exposure was also associated with risk of other NCDs. However, combined estrogen and progestin-containing hormonal contraception use was not statistically associated with risk of any NCDs.
机译：背景：激素避孕药在感染人类免疫缺陷病毒（HIV）的女性中很常见。在该人群中尚未描述使用激素避孕药的精神病和其他非感染性并发症的风险。方法：我们对1998年至2008年在田纳西州接受HIV感染的妇女进行了一项回顾性队列研究，以调查发生精神疾病和其他非传染性疾病（NCD）的风险，包括心血管，肝，肾，恶性疾病以及激素避孕使用包括醋酸甲羟孕酮（DMPA）以及含雌激素和孕激素的激素避孕药。我们使用具有反向概率权重的边际结构模型来说明与激素避孕使用相关的时变混杂因素。结果：在研究期间，在392名妇女中，有94名（24％）使用了激素避孕。接受和不接受激素避孕的妇女的基线精神疾病相似。有69例事件发生的精神病诊断和72例NCD。仅使用随时间变化的DMPA会增加精神疾病的风险（调整后的优势比[aOR] 3.70; 95％的置信区间[95％CI] 1.32-10.4）和情绪障碍，尤其是（aOR 4.70 [1.87-11.8]） 。随时间变化和累积激素组合使用与其他非传染性疾病没有统计学相关性（分别为aOR 1.64、95％CI 0.64-4.12和aOR 1.16、95％CI 0.86-1.56）。但是，随着累积DMPA暴露，发生非传染性疾病的风险增加（每年暴露aOR 1.45，95％CI 1.01-2.08）。结论：在感染艾滋病毒的妇女中，DMPA与使用期间发生精神疾病的风险有关，尤其是情绪障碍。 DMPA的累积暴露也与其他NCD的风险有关。然而，雌激素和孕激素联合激素避孕的使用与任何非传染性疾病的风险在统计学上均无关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号