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首页> 外文期刊>Journal of women’s health >Inclusion of women and gender-specific analyses in randomized clinical trials of treatments for depression.
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Inclusion of women and gender-specific analyses in randomized clinical trials of treatments for depression.

机译：在抑郁症的随机临床试验中纳入女性和针对性别的分析。

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BACKGROUND: The higher prevalence and cost of depression for women compared with men and the possible gender differences in treatment response demand the inclusion of women in clinical trials of depression treatments. The 1993 National Institutes of Health (NIH) Revitalization Act set a new standard, requiring investigators to consider the inclusion of women and analyze outcomes by gender, yet compliance with these standards in depression research has not been examined systematically. The purpose of this study is to examine the inclusion of women and gender-specific analyses in recent randomized clinical trials (RCTs) for depression. METHODS: RCTs were identified through a MEDLINE search for trials published between January 1 and December 31, 2007, and a Clinicaltrials.gov search of self-identified interventional studies to treat depression. RESULTS: Of the 150 RCTs for depression published in 2007, 15% did not report the gender composition of their sample, 50% of studies did not analyze outcomes by gender, and 12% controlled for gender but did not analyze for gender differences. Of the 768 trials reviewed on Clinicaltrials.gov, 89% reported recruiting male and female participants, yet <1% reported an intention to analyze results by gender. CONCLUSIONS: Many recent studies of depression treatments include women but do not examine outcomes by gender. Understanding how women differ from men in response to treatment is critical for enhancing treatment efficacy for the greatest number of adults with depression.
机译：背景：与男性相比，女性抑郁症的患病率和费用更高，并且治疗反应中可能存在性别差异，这要求将女性纳入抑郁症治疗的临床试验中。 1993年的《美国国家卫生研究院（NIH）振兴法案》设定了新的标准，要求研究人员考虑纳入女性并按性别分析结果，但是尚未对抑郁症研究中对这些标准的遵守情况进行过系统的检查。这项研究的目的是检查最近抑郁症的随机临床试验（RCT）中是否包括女性和针对性别的分析。方法：通过MEDLINE搜索2007年1月1日至12月31日发布的试验，以及通过Clinicaltrials.gov搜索自我识别的治疗抑郁症的干预性研究，确定RCT。结果：在2007年发布的150项抑郁抑郁RCT中，有15％未报告其样本的性别组成，有50％的研究未按性别分析结果，有12％的性别对照但未分析性别差异。在Clinicaltrials.gov上审查的768个试验中，有89％报告招募了男性和女性参与者，而只有不到1％的报告打算按性别分析结果。结论：最近对抑郁症治疗的许多研究都包括女性，但并未按性别检查结局。了解女性在治疗上与男性的不同之处对于提高对大多数抑郁症成年人的治疗效果至关重要。

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