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首页> 外文期刊>Journal of women’s health >Macronutrient composition and increased physical activity modulate plasma adipokines and appetite hormones during a weight loss intervention.
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Macronutrient composition and increased physical activity modulate plasma adipokines and appetite hormones during a weight loss intervention.

机译：在减肥干预过程中，大量营养成分和增加的体育活动会调节血浆脂肪因子和食欲激素。

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BACKGROUND: We have shown previously that in overweight premenopausal women, changes in macronutrient composition and increasing the number of steps walked per day favorably affect body composition and plasma lipid profiles. As a follow-up, we evaluated the effect of moderate carbohydrate intake and increased physical activity on inflammation and regulation of appetite. METHODS: Seventy premenopausal women with a body mass index (BMI) between 25 and 37 kg/m(2) participated in a 10-week weight loss intervention program consisting of the following macronutrient energy distribution: 40% carbohydrate, 30% fat, and 30% protein, in addition to a progressive increase in the number of steps taken per day. Plasma adiponectin, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), leptin, and ghrelin levels were assessed at baseline and after 10 weeks. RESULTS: Subjects reduced body weight by 4.5%, waist circumference (WC) by 6.4%, and trunk fat by 4.6%. Plasma insulin and insulin resistance assessed by homeostasis model assessment (HOMA) were reduced after 10 weeks (p < 0.01). Plasma adiponectin was increased by 11% (p < 0.05), and ICAM-1 levels were decreased (p < 0.05) after 10 weeks. A negative correlation was found between changes in insulin and changes in adiponectin between baseline and 10 weeks (r = -0.397, p < 0.01), indicating a role of adiponectin in increasing insulin sensitivity. In addition, plasma ghrelin levels were increased by 17% (p < 0.001), indicating a signal for increased appetite associated with weight loss. CONCLUSIONS: These studies indicate that weight loss interventions involving moderate changes in dietary carbohydrate and increases in physical activity favorably affect insulin sensitivity and decrease inflammation.
机译：背景：我们先前已经表明，在绝经前超重的妇女中，大量营养成分的变化和每天步行的步骤数量的增加有利地影响身体成分和血脂水平。作为后续研究，我们评估了适度摄入碳水化合物和增加体力活动对炎症和食欲调节的影响。方法：70名绝经前妇女的体重指数（BMI）在25至37 kg / m（2）之间，参加了为期10周的减肥干预计划，该计划包括以下宏观营养素能量分布：40％的碳水化合物，30％的脂肪和30％的蛋白质，以及每天逐步增加的步骤数。在基线和10周后评估血浆脂联素，细胞内粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1），瘦素和生长素释放肽水平。结果：受试者的体重降低了4.5％，腰围（WC）降低了6.4％，躯干脂肪降低了4.6％。 10周后血浆胰岛素和通过稳态模型评估（HOMA）评估的胰岛素抵抗降低（p <0.01）。 10周后血浆脂联素增加了11％（p <0.05），ICAM-1水平降低了（p <0.05）。在基线和10周之间，胰岛素变化与脂联素变化之间呈负相关（r = -0.397，p <0.01），表明脂联素在增加胰岛素敏感性中的作用。此外，血浆生长素释放肽水平增加了17％（p <0.001），表明与体重减轻相关的食欲增加。结论：这些研究表明减肥干预措施涉及饮食中碳水化合物的适度变化和体育活动的增加，有利于影响胰岛素敏感性并减少炎症。

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