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首页> 外文期刊>Journal of the Association for Research in Otolaryngology: JARO >Full-field thickness distribution of human tympanic membrane obtained with optical coherence tomography
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Full-field thickness distribution of human tympanic membrane obtained with optical coherence tomography

机译：光学相干层析成像技术获得的人鼓膜全视场厚度分布

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摘要

The full-field thickness distribution, three-dimensional surface model and general morphological data of six human tympanic membranes are presented. Cross-sectional images were taken perpendicular through the membranes using a high-resolution optical coherence tomography setup. Five normal membranes and one membrane containing a pathological site are included in this study. The thickness varies strongly across each membrane, and a great deal of inter-specimen variability can be seen in the measurement results, though all membranes show similar features in their respective relative thickness distributions. Mean thickness values across the pars tensa ranged between 79 and 97 μm; all membranes were thinnest in the central region between umbo and annular ring (50-70 μm), and thickness increased steeply over a small distance to approximately 100-120 μm when moving from the central region either towards the peripheral rim of the pars tensa or towards the manubrium. Furthermore, a local thickening was noticed in the antero-inferior quadrant of the membranes, and a strong linear correlation was observed between inferior-posterior length and mean thickness of the membrane. These features were combined into a single three-dimensional model to form an averaged representation of the human tympanic membrane. 3D reconstruction of the pathological tympanic membrane shows a structural atrophy with retraction pocket in the inferior portion of the pars tensa. The change of form at the pathological site of the membrane corresponds well with the decreased thickness values that can be measured there.
机译：介绍了六种人类鼓膜的全视场厚度分布，三维表面模型和一般形态学数据。使用高分辨率光学相干断层扫描装置垂直穿过膜截取横截面图像。这项研究包括五个正常膜和一个包含病理部位的膜。尽管所有膜在其各自的相对厚度分布中都表现出相似的特征，但整个膜的厚度变化很大，并且在测量结果中可以看到很大的种间差异。整个截面的平均厚度值在79至97μm之间;所有膜在超音波和环形圈之间的中央区域最薄（50-70μm），并且当从中央区域向pars tensa的外围边缘移动时，厚度在短距离内急剧增加到大约100-120μm。对着手。此外，在膜的前下象限中观察到局部增厚，并且在膜的下后长度和平均厚度之间观察到强烈的线性相关性。将这些特征组合到单个三维模型中，以形成人鼓膜的平均代表。病理性鼓膜的3D重建显示结构性萎缩，并在pars tensa的下半部有回缩袋。膜的病理部位的形式变化与在那里可以测得的减小的厚度值很好地对应。

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