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首页> 外文期刊>Diabetes, obesity & metabolism >Role of the clock gene Rev-erb in metabolism and in the endocrine pancreas
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Role of the clock gene Rev-erb in metabolism and in the endocrine pancreas

机译：Clock基因Rev-erb在新陈代谢和内分泌胰腺中的作用

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摘要

Several hormones are regulated by circadian rhythms to adjust the metabolism to the light/dark cycles and feeding/activity patterns throughout the day. Circadian rhythms are mainly governed by the central clock located in the suprachiasmatic nucleus but also by clocks present in peripheral organs, like the endocrine pancreas. Plasma glucose levels and the main pancreatic hormones insulin and glucagon also exhibit daily variations. Alterations in circadian rhythms are associated with metabolic disturbances and pathologies such as obesity and diabetes. The molecular components of central and peripheral clocks and their regulatory mechanisms are well established. Among the different clock genes, Rev-erb is considered one of the key links between circadian rhythms and metabolism. Rev-erb is a critical part of a negative feedback loop in the core circadian clock and modulates the clock oscillatory properties. In addition, Rev-erb plays an important role in the regulation of lipid and glucose metabolism, thermogenesis, adipocyte and muscle differentiation as well as mitochondrial function. In the endocrine pancreas, Rev-erb regulates insulin and glucagon secretion and pancreatic -cell proliferation. In the present review, we discuss all these subjects and, particularly, the role of the clock gene Rev-erb in the endocrine pancreas.
机译：昼夜节律调节几种激素，以全天调节新陈代谢，使其适应明/暗周期和进食/活动模式。昼夜节律主要受位于视交叉上核的中央时钟控制，也受周围器官如内分泌胰腺的时钟控制。血浆葡萄糖水平以及主要的胰激素胰岛素和胰高血糖素也表现出每日变化。昼夜节律的改变与代谢紊乱和诸如肥胖症和糖尿病的病理相关。中央和外围时钟的分子组成及其调节机制已得到很好的建立。在不同的时钟基因中，Rev-erb被认为是昼夜节律和新陈代谢之间的关键环节之一。 Rev-erb是核心生物钟中负反馈环路的关键部分，它调节时钟的振荡特性。此外，Rev-erb在调节脂质和葡萄糖代谢，生热，脂肪细胞和肌肉分化以及线粒体功能中起着重要作用。在内分泌胰腺中，Rev-erb调节胰岛素和胰高血糖素的分泌以及胰腺细胞的增殖。在本综述中，我们讨论了所有这些主题，尤其是时钟基因Rev-erb在内分泌胰腺中的作用。

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