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首页> 外文期刊>Diabetes/metabolism research and reviews >Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.
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Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.

机译：胆固醇氧化物是1型和2型糖尿病中氧化应激的生物标志物。

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BACKGROUND: Oxidative stress plays an important role in the pathophysiology of diabetes mellitus. The aim of this study was to evaluate the formation of cholesterol oxides (ChOx) as biomarkers of oxidative stress in subjects with impaired glucose tolerance (IGT) and diabetes. METHODS: Blood plasma levels of cholesterol oxidation products were determined in the following groups: type 1 diabetes mellitus (DM1), type 2 diabetes (DM2), impaired glucose tolerance (IGT), children without diabetes (C1) and adults without diabetes (C2). The serum levels of cholest-5-ene-3alpha,7alpha-diol (7alpha-hydroxycholesterol, 7alpha-OH), cholest-5-ene-3beta,7beta-diol (7beta-hydroxycholesterol, 7beta-OH), 3beta-hydroxycholest-5-7-one (7-ketocholesterol, 7-K), 5alpha-cholestane-3beta,5,6beta-triol (cholestanetriol), 5,6alpha-epoxy-5alpha-cholestan-3alpha-ol (cholesterol-5alpha,6alpha-epoxide,), 5,6beta-epoxy-5beta-cholestan-3beta-ol (cholesterol-5beta,6beta-epoxide) and cholest-5-eno-3beta,25-diol (25-hydroxycholesterol,25-OH) (trivial name and abbreviations indicated in parentheses) were quantified by gas chromatography using flame ionization detection. RESULTS: The levels of total ChOx were elevated in the DM1 and DM2 groups compared to age-matched subjects without diabetes (p < 0.05). The concentrations of 7beta-hydroxycholesterol, cholesterol-alpha-epoxide and cholesterol-beta-epoxide were higher in the blood plasma of subjects in the DM2 group than in the blood plasma of subjects in the C2 and IGT groups (p < 0.05). Treatment of type 2 diabetic patients with oral hypoglycemic drugs associated with insulin resulted in lower concentrations of nitrotyrosine in the blood plasma without significant changes in the concentrations of glucose and glycated hemoglobin. Moreover, combination with statins in both treatments decreased the concentrations of ChOx. CONCLUSIONS: ChOx are suitable biomarkers of oxidative stress and may be useful in clinical studies to follow drug effects on lipid oxidative modifications in diabetic patients.
机译：背景：氧化应激在糖尿病的病理生理中起着重要的作用。这项研究的目的是评估葡萄糖耐量（IGT）受损和糖尿病患者中氧化应激的生物标志物胆固醇氧化物（ChOx）的形成。方法：测定以下组中血浆胆固醇氧化产物的水平：1型糖尿病（DM1），2型糖尿病（DM2），糖耐量减低（IGT），无糖尿病儿童（C1）和无糖尿病成人（C2） ）。胆固醇5-3-3α，7α-二醇（7alpha-羟基胆固醇，7alpha-OH），胆固醇5-3-3，7beta-二醇（7beta-羟基胆固醇，7beta-OH），3beta-羟基胆固醇- 5-7-one（7-ketocholesterol，7-K），5alpha-cholestane-3beta，5,6beta-triol（cholestanetriol），5,6alpha-epoxy-5alpha-cholestan-3alpha-ol（cholesterol-5alpha，6alpha- ），5,6beta-环氧-5beta-cholestan-3beta-ol（cholesterol-5beta，6beta-epoxy）和cholest-5-eno-3beta，25-diol（25-hydroxycholesterol，25-OH）（俗称（括号中的缩写）通过使用火焰离子化检测的气相色谱法定量。结果：与没有糖尿病的年龄相匹配的受试者相比，DM1和DM2组的总ChOx水平升高（p <0.05）。 DM2组受试者的血浆中7β-羟基胆固醇，胆固醇-α-环氧化物和胆固醇-β-环氧化合物的浓度高于C2组和IGT组的受试者的血浆（p <0.05）。用与胰岛素相关的口服降糖药治疗2型糖尿病患者，血浆中的硝基酪氨酸浓度降低，而葡萄糖和糖化血红蛋白的浓度无明显变化。此外，在两种治疗中均与他汀类药物合用会降低ChOx的浓度。结论：ChOx是氧化应激的合适生物标志物，在临床研究中可用于追踪药物对糖尿病患者脂质氧化修饰的影响。

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