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首页> 外文期刊>Diabetes/metabolism research and reviews >Association between bone mineral density and type 1 diabetes mellitus: a meta-analysis of cross-sectional studies.
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Association between bone mineral density and type 1 diabetes mellitus: a meta-analysis of cross-sectional studies.

机译：骨矿物质密度与1型糖尿病之间的关联：对横断面研究的荟萃分析。

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A few studies have investigated the relationship between type 1 diabetes mellitus (T1DM) and bone mineral density (BMD) values. This meta-analysis was performed to explore differences between T1DM and healthy individuals in BMD values measured at five bone sites.We searched the database of PubMed for cross-sectional studies about the association of T1DM and BMD, and a meta-analysis was conducted.The results suggested significant association between T1DM and decreased BMD values of total body. The pooled mean differences (MDs) were -0.06 [95% confidence interval (CI): -0.11, -0.01] for all people. As for the association between T1DM and spine BMD values, the pooled MDs were -0.04 (95% CI: -0.07, -0.01) for males and -0.03 (95% CI: -0.06, 0.00) for females <20?years old. As for femur BMD values, the pooled MDs were -0.06 (95% CI: -0.13, 0.00) for all people, -0.03 (95% CI: -0.06, -0.01) for females and -0.04(95% CI: -0.05, -0.02) for males. As for hip BMD values, the pooled MDs were -0.06 (95% CI: -0.08, -0.04) for females. As for forearm BMD values, the pooled MDs were -0.01 (95% CI: -0.02, 0.00) for females.The results of this meta-analysis suggest the overall association between T1DM and reduced BMD values. Notably, the influence of T1DM on BMD seems to depend on gender or patient's age. Reduced BMD values may occur early after T1DM diagnosis. Future clinical and basic research studies are needed to further understand the mechanisms of decreased BMD values in T1DM patients. Copyright ? 2013 John Wiley & Sons, Ltd.
机译：一些研究调查了1型糖尿病（T1DM）与骨矿物质密度（BMD）值之间的关系。这项荟萃分析旨在探讨T1DM与健康个体在五个骨骼部位测得的BMD值之间的差异。我们在PubMed数据库中搜索了有关T1DM与BMD关联的横断面研究，并进行了荟萃分析。结果表明T1DM与全身BMD值降低之间存在显着关联。所有人的汇总平均差异（MDs）为-0.06 [95％置信区间（CI）：-0.11，-0.01]。至于T1DM与脊柱BMD值之间的关联，男性（20岁以下）的合并MD为-0.04（95％CI：-0.07，-0.01），女性为-0.03（95％CI：-0.06，0.00）。 。至于股骨的BMD值，所有人群的MD值均为-0.06（95％CI：-0.13，0.00），女性为-0.03（95％CI：-0.06，-0.01），-0.04（95％CI ：-） 0.05，-0.02）（男性）。至于髋部BMD值，女性的合并MD为-0.06（95％CI：-0.08，-0.04）。至于前臂的BMD值，女性的合并MDs为-0.01（95％CI：-0.02，0.00）。这项荟萃分析的结果表明T1DM与降低的BMD值总体相关。值得注意的是，T1DM对BMD的影响似乎取决于性别或患者的年龄。 T1DM诊断后早期可能会降低BMD值。需要进一步的临床和基础研究来进一步了解T1DM患者BMD值降低的机制。版权？ 2013 John Wiley＆Sons，Ltd.

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