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首页> 外文期刊>Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research >Influence of surgical procedures on interleukin-6 and monocyte chemotactic and activating factor responses: CABG vs. valvular surgery.
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Influence of surgical procedures on interleukin-6 and monocyte chemotactic and activating factor responses: CABG vs. valvular surgery.

机译：外科手术对白介素6和单核细胞趋化和激活因子反应的影响：CABG与瓣膜手术。

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Interleukin-6 (IL-6) and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1) play pivotal roles in systemic inflammation, immune response, and tissue damage after cardiopulmonary bypass (CPB). Previous reports have described transient rises in IL-6 and MCAF after CPB, but the data seem to vary according to the different surgical procedures used. To evaluate the influence of the different surgical procedures on the proinflammatory cytokine responses, we compared perioperative serum IL-6 and MCAF release in coronary artery bypass grafting (CABG) and valvular surgery cases. Eighteen CABG (CABG group) and 7 single valvular cardiac surgery patients (valve group) were included in this study. Blood samples were taken to measure the serum concentrations of IL-6 at the induction of anesthesia, at the removal of the aortic cross-clamp, at the end of CPB, at the end of surgery, and 24 h after the termination of surgery. Serum IL-6 and MCAF were assayed by ELISA. Serum IL-6 increased immediately after aortic declamping and reached its peak at the end of surgery in both groups. Serum IL-6 concentrations at the end of surgery and 24 h after surgery were significantly higher in the valve group than in the CABG group (123.9 +/- 21.7 pg/ml vs. 79.7 +/- 10.4 pg/ml, p = 0.049; 113.6 +/- 25.0 pg/ml vs. 39.9 +/- 11.5 pg/ml, p = 0.006, respectively). Serum MCAF increased immediately after aortic declamping, and the MCAF level at the end of surgery was significantly higher in the valve group than in the CABG group (1118.4 +/- 353.9 pg/ml vs. 241.0 +/- 71.2 pg/ml, p = 0.002, respectively). IL-6 and MCAF may play important roles in the pathophysiology of surgical damage with CPB, and the different surgical procedures appear to affect the proinflammatory cytokine release after cardiac surgery differently.
机译：白细胞介素6（IL-6）和单核细胞趋化和激活因子/单核细胞趋化蛋白1（MCAF / MCP-1）在体外循环（CPB）后的全身炎症反应，免疫反应和组织损伤中起关键作用。先前的报道描述了CPB后IL-6和MCAF的短暂升高，但是数据似乎根据所使用的不同手术程序而有所不同。为了评估不同手术程序对促炎细胞因子反应的影响，我们比较了冠状动脉旁路移植术（CABG）和瓣膜手术病例的围手术期血清IL-6和MCAF释放。这项研究包括18位CABG（CABG组）和7位单瓣心脏手术患者（瓣膜组）。在麻醉诱导，CPB结束时，手术结束时和手术终止后24小时，抽取血样以测量诱导麻醉时，去除主动脉夹钳时的IL-6血清浓度。通过ELISA测定血清IL-6和MCAF。两组主动脉钳夹后血清IL-6立即升高，并在手术结束时达到峰值。瓣膜组手术结束时和手术后24 h的血清IL-6浓度明显高于CABG组（123.9 +/- 21.7 pg / ml与79.7 +/- 10.4 pg / ml，p = 0.049 ; 113.6 +/- 25.0 pg / ml与39.9 +/- 11.5 pg / ml，p = 0.006）。主动脉放松后血清MCAF立即升高，并且瓣膜组手术结束时的MCAF水平明显高于CABG组（1118.4 +/- 353.9 pg / ml vs. 241.0 +/- 71.2 pg / ml，p分别为0.002）。 IL-6和MCAF在CPB手术损伤的病理生理中可能起重要作用，并且不同的手术程序似乎对心脏手术后促炎性细胞因子的释放产生不同的影响。

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