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首页> 外文期刊>Journal of cellular biochemistry. >Risks and Benefits of Bisphosphonate Therapies
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Risks and Benefits of Bisphosphonate Therapies

机译：双膦酸盐疗法的风险和益处

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Bisphosphonates are the mainstay of osteoporosis treatment but also play a fundamental role in treating other bone diseases such as Osteogenesis Imperfecta, Pagets' disease, and in the prevention of adverse skeletal effects in certain cancers such as prostate cancer or multiple myeloma. In the last decades, the refinement of bisphosphonates and an increase in the number of new bisphosphonates commercialized has altered the clinical management of these diseases. Despite differences between randomized controlled trials and observational studies, overall all bisphosphonates licensed have proven to reduce the risk of fracture through the inhibition of bone resorption. Other beneficial effects include pain reduction in bone metastasis and potentially a decrease in mortality. However, the chronic nature of most of these disorders implies long-term treatments, which can be associated with long-term adverse effects. Some of the adverse effects identified include an increased risk of atypical femur fractures, osteonecrosis of the jaw, gastrointestinal side effects, or atrial fibrillation. The harm/benefit thinking and the constant update regarding these medications are vital in the day-to-day decision-making in clinical practices. The aims of this review are to compile the basic characteristics of these drugs and outline the most important benefits and side effects and provide a clinical context as well as a research agenda to fill the gaps in our knowledge. (C) 2015 Wiley Periodicals, Inc.
机译：双膦酸盐是骨质疏松症治疗的主要手段，但在治疗其他骨病（例如成骨不全症，Pagets病）以及预防某些癌症（例如前列腺癌或多发性骨髓瘤）的不良骨骼作用中也起着基本作用。在过去的几十年中，双膦酸盐的精制和商业化新双膦酸盐的数量的增加改变了这些疾病的临床管理。尽管随机对照试验和观察性研究之间存在差异，但总的来说所有获得许可的双膦酸盐已被证明可通过抑制骨吸收来降低骨折的风险。其他有益作用包括减轻骨转移的疼痛，并可能降低死亡率。然而，大多数这些疾病的慢性性质意味着长期治疗，这可能与长期不良反应有关。确定的一些不良反应包括非典型股骨骨折，颌骨坏死，胃肠道副作用或心房颤动的风险增加。关于这些药物的危害/益处思考和不断更新对于临床实践的日常决策至关重要。这篇综述的目的是汇编这些药物的基本特征，概述最重要的益处和副作用，并提供临床背景以及旨在填补我们知识空白的研究议程。 （C）2015威利期刊公司

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