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首页> 外文期刊>Clinical and experimental hypertension: CEH >Relationship between cardio-ankle vascular index and homocysteine in hypertension subjects with hyperhomocysteinemia
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Relationship between cardio-ankle vascular index and homocysteine in hypertension subjects with hyperhomocysteinemia

机译：高同型半胱氨酸血症高血压患者心踝血管指数与同型半胱氨酸的关系

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Background: Arteriosclerosis evaluated by arterial stiffness is the basic pathophysiological change during the development of hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness. Hyperhomocysteinemia (HHcy) is an independent risk factor for vascular diseases. However, there was little research about the relationship between CAVI and homocysteine (Hcy) in hypertension subjects with HHcy. Methods: A total of 330 subjects (M/F 133/197) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: control group (group 1, normotensive with normal Hcy, n = 149), hypertension group (group 2, n = 113), HHcy group (group 3, n = 30), and hypertension with HHcy group (group 4, n = 38). CAVI was measured by VS-1000 apparatus. Results: Our results showed that CAVI was significantly higher in group 4 than in group 1 and group 2 (8.41 +/- 1.08 vs. 7.79 +/- 1.14; 8.41 +/- 1.08 vs. 7.87 +/- 1.02, both p < 0.05, respectively). Positive correlation between CAVI and Hcy was found in the entire study group (r = 0.109, p = 0.049) and hypertension subjects (group 2 + group 4; r = 0.202, p = 0.014). Multivariate analysis showed that Hcy was an independent associating factor of CAVI in all subjects ( = 0.251, p = 0.034). Conclusions: The present study showed that CAVI was significantly higher in hypertension subjects with HHcy compared to hypertension group. There was significant correlation between CAVI and Hcy, indicating the relationship between arterial stiffness and biomarkers in vascular-related diseases.
机译：背景：通过动脉僵硬度评估的动脉硬化是高血压发展过程中的基本病理生理变化。心踝血管指数（CAVI）是动脉僵硬度的指数。高同型半胱氨酸血症（HHcy）是血管疾病的独立危险因素。然而，关于高血压患者中CAVI与高半胱氨酸（Hcy）之间关系的研究很少。方法：将北京大学首钢医院血管内科的330名受试者（M / F 133/197）分为四组：对照组（第1组，Hcy正常，血压正常，n = 149），高血压组（第2组）。 ，n = 113），HHcy组（第3组，n = 30）和高血压伴HHcy组（第4组，n = 38）。 CAVI通过VS-1000仪器测量。结果：我们的结果表明，第4组的CAVI显着高于第1组和第2组（8.41 +/- 1.08对7.79 +/- 1.14; 8.41 +/- 1.08对7.87 +/- 1.02，两者均p < 0.05）。在整个研究组（r = 0.109，p = 0.049）和高血压受试者（组2 +组4; r = 0.202，p = 0.014）中发现CAVI和Hcy之间呈正相关。多变量分析表明，Hcy是所有受试者中CAVI的独立关联因子（= 0.251，p = 0.034）。结论：本研究表明，与高血压组相比，HHcy高血压患者的CAVI显着更高。 CAVI和Hcy之间存在显着相关性，表明在血管相关疾病中动脉僵硬度和生物标志物之间的关系。

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