...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular biochemistry. >Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together?
【24h】

Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together?

机译：染色质重塑，组蛋白修饰和DNA甲基化-它们如何融合在一起？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns. J. Cell. Biochem. 87: 117-125, 2002. Published 2002 Wiley-Liss, Inc.
机译：DNA甲基化在控制基因转录和染色质结构中很重要。与其他表观遗传机制的关系刚刚开始阐明该过程的复杂性。在组蛋白甲基化和染色质重塑领域激动人心的新研究表明，这些不同机制与DNA甲基化之间的联系对于控制染色体结构和基因表达有多么重要。新兴证据表明，染色质重塑酶和组蛋白甲基化对于正确的DNA甲基化模式至关重要。其他组蛋白修饰（例如乙酰化和磷酸化）反过来会影响组蛋白甲基化，组蛋白甲基化也似乎高度依赖于染色质重塑酶。这篇综述将总结可能只是大量新信息的开始，这些信息最终将链接哺乳动物基因组的所有表观遗传修饰。还将提出一个模型来说明染色质修饰如何导致基因组DNA甲基化模式。 J.细胞。生化。 87：117-125，2002。2002年Wiley-Liss，Inc.发布。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号