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首页> 外文期刊>Journal of cellular biochemistry. >Effect of fibroblast growth factors 1, 2, 4, 5, 6, 7, 8, 9, and 10 on avian chondrocyte proliferation.
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Effect of fibroblast growth factors 1, 2, 4, 5, 6, 7, 8, 9, and 10 on avian chondrocyte proliferation.

机译：成纤维细胞生长因子1、2、4、5、6、7、8、9和10对禽软骨细胞增殖的影响。

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摘要

It has been demonstrated that fibroblast growth factor receptors are key regulators of endochondral bone growth. However, it has not been determined what fibroblast growth factor ligand(s) (FGFs) are important in this process. This study sought to determine whether FGFs 1, 2, 4, 5, 6, 7, 8, 9, and 10 were capable of stimulating avian chondrocyte proliferation in vitro. We have found that FGFs 2, 4, and 9 strongly stimulate avian chondrocyte proliferation while FGFs 6 and 8 stimulate proliferation to a lesser extent. RT-PCR indicates that FGF-2 and FGF-4 are expressed in the postnatal avian epiphyseal growth plate (EGP) while FGF-8 and FGF-9 are not. Thus, FGF-2 and FGF-4 stimulate chondrocyte proliferation and are both present in the EGP. This suggests that FGF-2 and FGF-4 may be important ligands, in vivo, for the regulation of endochondral bone growth. These observations coupled with our observation that multiple avian FGF receptors (Cek1, Cek2, Cek3, and FREK) are expressed in proliferative chondrocytes highlights the complexity of FGF signaling pathways in postnatal endochondral bone growth.
机译：已经证明成纤维细胞生长因子受体是软骨内骨生长的关键调节剂。但是，尚未确定在此过程中重要的成纤维细胞生长因子配体（FGF）是否重要。这项研究试图确定FGF 1、2、4、5、6、7、8、9和10是否能够在体外刺激禽软骨细胞增殖。我们发现FGF 2、4和9强烈刺激禽软骨细胞增殖，而FGF 6和8刺激程度较小。 RT-PCR表明，FGF-2和FGF-4在出生后的鸡骨phy生长板（EGP）中表达，而FGF-8和FGF-9则不表达。因此，FGF-2和FGF-4刺激软骨细胞增殖并且均存在于EGP中。这表明FGF-2和FGF-4在体内可能是调节软骨内骨生长的重要配体。这些观察结果与我们在增殖性软骨细胞中表达多种禽类FGF受体（Cek1，Cek2，Cek3和FREK）的观察结果一起突显了出生后软骨内骨生长中FGF信号通路的复杂性。

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