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首页> 外文期刊>Journal of Surgical Oncology >High Pin1 expression is associated with tumor progression in colorectal cancer.
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High Pin1 expression is associated with tumor progression in colorectal cancer.

机译：Pin1的高表达与大肠癌的肿瘤进展有关。

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BACKGROUND AND OBJECTIVES: Peptidyl prolyl cis-trans isomerase (Pin1) isomerizes only phosphorylated serine or threonine residues preceding proline in certain proteins and affects the protein function. Pin1 interacts with many signaling pathways, including Wnt signaling pathway that is crucial for colorectal tumorigenesis. Pin1 promotes cyclin D1 over-expression directly or through the stabilization of beta-catenin. Pin1 is over-expressed in some cancers such as prostate and breast cancers. This study aimed to determine whether Pin1 plays a role in colorectal tumorigenesis through the upregulation of beta-catenin and cyclin D1. METHODS: Immunohistochemical analyses were performed on 105 colorectal cancer tissue samples using anti-Pin1, anti-beta-catenin, and anti-cyclin D1 antibodies. We examined the relationships between Pin1 expression and clinicopathological factors, prognosis, and beta-catenin/cyclin D1 expression. RESULTS: High Pin1 expression was observed in 40 cases (38%) and positively correlated with histological type (P=0.0240), depth of invasion (P=0.0051), and staging (P=0.0027) of colorectal tumors. High Pin1 expression was also correlated with the over-expressions of both beta-catenin (P=0.0225) and cyclin D1 (P=0.0137). CONCLUSIONS: These results suggest that Pin1 plays an important role in colorectal tumorigenesis, presumably by increasing beta-catenin and cyclin D1 expressions.
机译：背景和目的：肽基脯氨酰顺反异构酶（Pin1）仅使某些蛋白质中脯氨酸之前的磷酸化丝氨酸或苏氨酸残基异构化，并影响蛋白质功能。 Pin1与许多信号通路相互作用，包括对结肠直肠肿瘤发生至关重要的Wnt信号通路。 Pin1直接或通过稳定β-catenin促进细胞周期蛋白D1过表达。 Pin1在某些癌症（例如前列腺癌和乳腺癌）中过表达。这项研究旨在确定Pin1是否通过β-catenin和cyclin D1的上调在结直肠肿瘤发生中起作用。方法：使用抗Pin1，抗β-catenin和抗细胞周期蛋白D1抗体对105个结直肠癌组织样本进行了免疫组织化学分析。我们检查了Pin1表达与临床病理因素，预后和β-catenin/ cyclin D1表达之间的关系。结果：40例患者中Pin1高表达（38％），与大肠肿瘤的组织学类型（P = 0.0240），浸润深度（P = 0.0051）和分期（P = 0.0027）呈正相关。 Pin1的高表达也与β-catenin（P = 0.0225）和cyclin D1（P = 0.0137）的过表达相关。结论：这些结果表明Pin1在大肠癌的发生中起重要作用，大概是通过增加β-catenin和cyclin D1的表达。

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