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首页> 外文期刊>Journal of Surgical Oncology >The prediction of lymph node metastasis in ductal carcinoma in situ with microinvasion by assessing lymphangiogenesis.
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The prediction of lymph node metastasis in ductal carcinoma in situ with microinvasion by assessing lymphangiogenesis.

机译：通过评估淋巴管生成来预测微浸润原位导管癌的淋巴结转移。

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摘要

BACKGROUND AND OBJECTIVES: Lymph node (LN) metastasis of ductal carcinoma in situ with microinvasion (DCISM) is variable (0-14%). To ascertain the role of lymphangiogenesis in LN metastasis in DCISM, we compared the lymphatic vessel density with the presence of LN metastasis in a group of patients that underwent axillary dissection with breast surgery due to DCISM. METHODS: We identified 46 patients with a diagnosis of DCISM who underwent breast surgery with axillary dissection to evaluate LN status from June 1996 to March 2008. Microvessel density (MVD) and lymphatic vessel density (LVD) was measured by immunohistochemical staining with two markers, CD34 and D2-40. RESULTS: LVD of the patients with LN metastasis was significantly higher than that of the patients without LN metastasis (P = 0.04). Correlation in the total score of progesterone receptor and LN metastasis was also noted (P = 0.017). There was no statistically significant relation between LVD and clinicopathologic parameters such as size and type of underlying DCIS, nuclear grade, presence of lymphovascular invasion, hormone receptor, and HER-2 status. CONCLUSIONS: Lymphangiogenesis may be significantly associated with LN metastasis in DCISM. This is the first attempt to predict axillary LN metastasis in DCISM by quantifying the LVD.
机译：背景与目的：导管癌原位微浸润（DCISM）淋巴结（LN）转移是可变的（0-14％）。为了确定淋巴管生成在DCISM中LN转移中的作用，我们比较了因DCISM进行了腋窝淋巴结清扫术的一组患者的淋巴管密度与LN转移的存在。方法：我们从1996年6月至2008年3月，对46例诊断为DCISM的患者进行了腋窝淋巴结清扫术以评估LN状况。采用两种标记物的免疫组织化学染色检测微血管密度（MVD）和淋巴管密度（LVD）， CD34和D2-40。结果：有LN转移的患者的LVD明显高于无LN转移的患者（P = 0.04）。还注意到孕激素受体总评分与LN转移的相关性（P = 0.017）。 LVD与临床病理学参数（例如潜在DCIS的大小和类型，核分级，淋巴管浸润的存在，激素受体和HER-2状态）之间无统计学意义的相关性。结论：DCISM中淋巴管生成可能与LN转移密切相关。这是通过量化LVD预测DCISM中腋窝LN转移的首次尝试。

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