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首页> 外文期刊>Journal of Surgical Oncology >Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma.
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Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma.

机译：软骨肉瘤中程序性细胞死亡5下调表达的预后意义。

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BACKGROUND AND OBJECTIVES: Programmed Cell Death 5 (PDCD5) is a novel apoptosis-related gene and deregulation of PDCD5 is involved in tumorigenicity. This study was designed to investigate the expression level of PDCD5 and to clarify its clinical significance in chondrosarcoma. METHODS: The mRNA and protein levels of PDCD5 in chondrosarcoma and matched corresponding non-tumor tissues were evaluated by real-time PCR and Western blot, respectively. The expression of PDCD5 protein was investigated by immunohistochemistry assays in chondrosarcoma, and its association with clinicopathologic factors and overall survival was also analyzed. RESULTS: The mRNA and protein levels of PDCD5 were significantly decreased in chondrosarcoma compared with corresponding non-tumor tissues. Low expression of PDCD5 protein was 61.8% (21/34) in chondrosarcomas, as compared 12.5% (1/8) in normal bones, as well as compared 23.5% (4/17) in benign cartilage tumors. PDCD5 expression was correlated with anatomical location and histological grade. The survival rate of patients with low-PDCD5 tumors was lower than that of patients with high-PDCD5 tumors. Multivariate analysis revealed that the downregulated expression of PDCD5 was an independent prognostic factor for overall survival. CONCLUSIONS: PDCD5 is downregulated in chondrosarcoma and might be an independent prognostic factor for overall survival of chondrosarcoma patients.
机译：背景与目的：程序性细胞死亡5（PDCD5）是一种新型的凋亡相关基因，PDCD5的失调与致瘤性有关。本研究旨在研究PDCD5的表达水平，并阐明其在软骨肉瘤中的临床意义。方法：采用实时荧光定量PCR和Western blot方法分别检测软骨肉瘤及相应的非肿瘤组织中PDCD5的mRNA和蛋白水平。用免疫组织化学方法检测PDCD5蛋白在软骨肉瘤中的表达，并分析其与临床病理因素和总生存期的关系。结果：与相应的非肿瘤组织相比，软骨肉瘤中PDCD5的mRNA和蛋白水平明显降低。 PDCD5蛋白在软骨肉瘤中的低表达率为61.8％（21/34），而在正常骨骼中为12.5％（1/8），在良性软骨肿瘤中为23.5％（4/17）。 PDCD5表达与解剖位置和组织学分级相关。低PDCD5肿瘤患者的生存率低于高PDCD5肿瘤患者的生存率。多变量分析显示PDCD5表达下调是整体生存的独立预后因素。结论：PDCD5在软骨肉瘤中被下调，可能是软骨肉瘤患者总体生存的独立预后因素。

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