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首页> 外文期刊>Journal of Surgical Oncology >Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma.
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Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma.

机译：胰十二指肠切除术治疗胰腺癌术后术中液体量对围手术期结局的影响。

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摘要

BACKGROUND: Excess use of intravenous fluid can increase post-operative complications. We examined the influence of intra-operative crystalloid (IOC) administration on complications following pancreaticodudenectomy (PD) for pancreatic adenocarcinoma. METHODS: We categorized 188 patients who underwent PD for adenocarcinoma (1990-2009) into two groups: Group I received <6,000 ml and Group II received >/=6,000 ml IOC. Differences between groups in length of stay, overall morbidity, and 30-day mortality were evaluated. RESULTS: There were 86 patients in Group I and 102 in Group II. Group I patients were older and with higher percentage of women, but similar in regards to performance status, ASA score, underlying comorbidities, and administration of neo-adjuvant treatment. Group II patients had longer operations, increased blood loss, and higher rates of intra-operative blood transfusions. There were two post-operative deaths, both in the Group II (P = 0.5). Post-operative overall morbidity was 45.7%, without differences between the two groups (44.2% vs. 47.1%, P = 0.7). Likewise, length of post-operative stay was similar in both groups (13.8 days vs. 14.5 days, P = 0.5). CONCLUSIONS: The volume of IOC increased with duration of surgery, intra-operative blood losses, and intra-operative blood transfusion, but did not correlate with post-operative morbidity.
机译：背景：过量使用静脉输液会增加术后并发症。我们检查了胰十二指肠切除术（PD）胰腺腺癌术后术中使用晶体（IOC）对并发症的影响。方法：我们将188例行PD腺癌PD治疗的患者（1990-2009年）分为两组：第一组接受<6,000 ml，第二组接受> / = 6,000 ml IOC。评估了两组患者的住院时间，总体发病率和30天死亡率之间的差异。结果：第一组86例，第二组102例。第一组患者年龄较大，女性比例较高，但在表现状态，ASA评分，潜在合并症和新辅助治疗方面相似。第二组患者手术时间更长，失血量更多，术中输血率更高。第二组有两个术后死亡（P = 0.5）。术后总体发病率为45.7％，两组之间没有差异（44.2％对47.1％，P = 0.7）。同样，两组的术后住院时间相似（分别为13.8天和14.5天，P = 0.5）。结论：IOC的量随手术时间，术中失血量和术中输血而增加，但与术后发病率无关。

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