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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Platelets: The universal killer?
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Platelets: The universal killer?

机译：血小板：全能杀手？

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摘要

For many, the final terminal event in life is cessation of the heart beat. In turn, this is generally because this organ has been deprived of oxygen and glucose as the blood can no longer deliver these requirements to the myocardium. The principal reason for this is blockage of one or more coronary arteries or arterioles by platelet rich thrombus. A similar process exists for the pathophysiology of stroke—a disabilitating and often fatal event caused by occlusion or rupture of arteries in, or feeding, the brain. These scenarios are best developed in cardiovascular disease, but apply to almost all human disease. Therefore, the ultimate culprit for these major life events is the overactive platelet—too ready to form an inappropriate thrombus. Thus, one way forward in postponing an occlusive thrombotic event is to minimise platelet activation, new tools and treatments for which are eagerly sought.
机译：对于许多人来说，生命中最后的终极事件是心跳停止。反过来，这通常是因为该器官已被剥夺了氧气和葡萄糖，因为血液无法再将这些需求传递给心肌。其主要原因是富含血小板的血栓阻塞了一个或多个冠状动脉或小动脉。中风的病理生理学也存在类似的过程-由大脑中动脉的阻塞或破裂或进食引起的使人丧失活力的致命事件。这些情况最适合心血管疾病，但几乎适用于所有人类疾病。因此，这些主要生活事件的最终罪魁祸首是血小板过度活跃，它太容易形成不适当的血栓。因此，推迟闭塞性血栓形成事件的一种方法是使血小板活化最小化，为此迫切地寻求新的工具和治疗方法。

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