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首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >H-ferritin and CD68(+)/H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease
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H-ferritin and CD68(+)/H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease

机译：成年Still病患者皮肤中的H-铁蛋白和CD68（+）/ H-铁蛋白（+）单核细胞/巨噬细胞增加，并且与该疾病的多脏器受累相关

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Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein composed of 24 subunits, heavy (H) subunits and light (L) subunits. The ferritin enriched in L subunits (L-ferritin) and the ferritin enriched in H subunits (H-ferritin) may be observed in different tissues. In this work, we aimed to investigate the skin expression of both Hand L-ferritin and the number of macrophages expressing these molecules from AOSD patients with persistent cutaneous lesions. We observed an increased expression of H-ferritin in the skin, associated with an infiltrate in the biopsies obtained from persistent cutaneous lesions of AOSD patients. Furthermore, a positive correlation between H-ferritin skin levels as well as the number of CD68(+)/H-ferritin(+) cells and the multi-visceral involvement of the disease was observed. Our data showed an increased expression of H-ferritin in the skin of AOSD patients, associated with a strong infiltrate of CD68(+)/H-ferritin(+) cells. Furthermore, a correlation between the levels of H-ferritin as well as of the number of CD68(+)/H-ferritin(+) cells and the multi-visceral involvement of the disease was observed.
机译：成人发作的斯蒂尔氏病（AOSD）患者可能会出现发烧的鲑鱼粉红色斑，并在不发烧的情况下减少。一些患者可能会经历数周的喷发。在AOSD期间，可能会观察到血清铁蛋白水平异常高;它是一种铁储存蛋白，由24个亚基，重（H）亚基和轻（L）亚基组成。可以在不同组织中观察到富含L亚基的铁蛋白（L-铁蛋白）和富含H亚基的铁蛋白（H-铁蛋白）。在这项工作中，我们旨在研究Hand L-铁蛋白的皮肤表达以及来自患有持续性皮肤病变的AOSD患者的表达这些分子的巨噬细胞的数量。我们观察到H-铁蛋白在皮肤中的表达增加，与从AOSD患者的持续性皮肤病变获得的活检组织浸润有关。此外，观察到H-铁蛋白的皮肤水平以及CD68（+）/ H-铁蛋白（+）细胞的数量与疾病的多内脏受累之间呈正相关。我们的数据显示，AOSD患者皮肤中H-铁蛋白的表达增加，与CD68（+）/ H-铁蛋白（+）细胞的强烈浸润有关。此外，观察到H-铁蛋白水平以及CD68（+）/ H-铁蛋白（+）细胞数量与疾病的多脏器累及之间的相关性。

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