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首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >Increased frequency of CD4 CD25 regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients.
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Increased frequency of CD4 CD25 regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients.

机译：脑脊液中CD4 CD25调节性T细胞的频率增加，但多发性硬化症患者血液中的CD4 CD25调节性T细胞的频率增加。

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Summary Naturally occurring CD4(+) CD25(+) regulatory T cells (nT(reg)) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4(+) CD25(+) nT(reg) have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4(+) CD25(+) nT(reg) in peripheral blood and CSF from MS patients (n = 14), patients with other neurological disorders (OND; n = 9) and compared peripheral levels with healthy controls (n = 40). We found that the frequency of CD4(+) CD25(+) forkhead transcription factor 3 (FOXP3)(+) nT(reg) was significantly elevated in the CSF from MS patients (mean CSF = 4.05+/- 1.54% versus mean peripheral blood = 2.93 +/- 0.94%) but not from patients with other neurological disorders (mean CSF = 3.78 +/- 1.26% versus mean peripheral blood = 3.74 +/- 1.4%). The frequency of nT(reg) in the periphery did not differ between MS patients and healthy donors; however, nT(reg) from MS patients showed reduced suppressive capacity.
机译：小结天然存在的CD4（+）CD25（+）调节性T细胞（nT（reg））通过抑制自身反应性T细胞在控制自身免疫中起主要作用。多发性硬化症（MS）是中枢神经系统（CNS）的炎症性脱髓鞘疾病，其中T细胞在协调组织损伤中起关键作用。尽管已对MS患者的外周血中的CD4（+）CD25（+）nT（reg）进行了研究，但对它们在靶器官（中枢神经系统）中的存在及其可能的功能知之甚少。为了研究在病理条件下脑脊液（CSF）中是否存在这些细胞，我们分析了MS患者外周血和CSF中CD4（+）CD25（+）nT（reg）的频率（n = 14） ），患有其他神经系统疾病的患者（OND; n = 9），并与健康对照组（n = 40）进行了外周血水平比较。我们发现，MS患者的CSF中CD4（+）CD25（+）前叉转录因子3（FOXP3）（+）nT（reg）的频率显着升高（相对于平均外周血，CSF = 4.05 +/- 1.54％血液= 2.93 +/- 0.94％），但不是来自患有其他神经系统疾病的患者（平均CSF = 3.78 +/- 1.26％，而平均外周血= 3.74 +/- 1.4％）。 MS患者和健康捐献者外周的nT（reg）频率无差异。但是，来自MS患者的nT（reg）显示抑制能力降低。

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