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首页> 外文期刊>Clinical and experimental medicine >OxLDL- and HSP-60 antigen-specific CD8+ T lymphocytes are detectable in the peripheral blood of patients suffering from coronary artery disease
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OxLDL- and HSP-60 antigen-specific CD8+ T lymphocytes are detectable in the peripheral blood of patients suffering from coronary artery disease

机译：在患有冠心病的患者的外周血中可检测到OxLDL和HSP-60抗原特异性CD8 + T淋巴细胞

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Abstracts: Inflammatory and immunologic mechanisms are important for the initiation and the progression of atherosclerotic lesions. OxLDL and HSP-60 antigens are involved in the pathogenesis of atherosclerotic disease by triggering immune cells within the plaques. Through the MHC pentamer assays, we investigated the presence of OxLDL- and HSP-60-specific CD8+ T lymphocytes in twenty HLA-A2-positive patients suffering from coronary artery disease (10 NSTEMI and 10 stable angina). Similarly, 10 age- and sex-matched healthy subjects were enrolled as controls. Biological samples were collected within 6 h of admission to hospital, at 30 days and at 180 days. OxLDL- and HSP-60-specific CD8+ T lymphocytes were never detectable in the peripheral blood from all the healthy controls. On the contrary, at each scheduled time point, both of these specific cells could be detected in peripheral blood from all enrolled patients. More in detail, the flow cytometric analysis of MHC-1 pentamer OxLDL-specific CD8+ T lymphocytes revealed a sharp and significant increase at the hospital admission, within 6 h from the chest pain onset, followed by an evident decline to lower levels at 30 days and at 180 days from the enrollment in the study. On the contrary, although MHC-1 pentamer HSP-60 CD8+ T lymphocytes were detectable in enrolled patients, almost no variance could be detectable during the follow-up scheduled evaluations. On the whole, this finding indicates that HSP-60- and OxLDL-specific CD8+ T lymphocytes could play a role in the maintenance or worsening of the atherosclerotic coronary disease.
机译：摘要：炎症和免疫机制对动脉粥样硬化病变的发生和发展至关重要。 OxLDL和HSP-60抗原通过触发斑块内的免疫细胞参与动脉粥样硬化疾病的发病机制。通过MHC五聚体测定，我们调查了20例患有冠心病（10 NSTEMI和10稳定型心绞痛）的HLA-A2阳性患者中OxLDL和HSP-60特异性CD8 + T淋巴细胞的存在。同样，将10名年龄和性别匹配的健康受试者作为对照。入院后6小时内，30天和180天收集生物样品。在所有健康对照者的外周血中均从未检测到OxLDL和HSP-60特异性CD8 + T淋巴细胞。相反，在每个预定的时间点，都可以从所有入组患者的外周血中检测到这两种特异性细胞。更详细地，对MHC-1五聚体OxLDL特异性CD8 + T淋巴细胞的流式细胞术分析显示，入院后胸痛发作后6小时内急剧增加，然后在30天时明显下降至较低水平并自研究纳入之日起180天。相反，尽管在入组患者中可检测到MHC-1五聚体HSP-60 CD8 + T淋巴细胞，但在计划的随访评估中几乎没有检测到差异。总体而言，这一发现表明，HSP-60和OxLDL特异性CD8 + T淋巴细胞可能在动脉粥样硬化性冠状动脉疾病的维持或恶化中发挥作用。

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