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首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >Serum concentration of immunoglobulin G-type antibodies against the whole Epstein-Barr nuclear antigen 1 and its aa35-58 or aa398-404 fragments in the sera of patients with systemic lupus erythematosus and multiple sclerosis
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Serum concentration of immunoglobulin G-type antibodies against the whole Epstein-Barr nuclear antigen 1 and its aa35-58 or aa398-404 fragments in the sera of patients with systemic lupus erythematosus and multiple sclerosis

机译：系统性红斑狼疮多发性硬化症患者血清中针对全爱泼斯坦-巴尔核抗原1及其aa35-58或aa398-404片段的免疫球蛋白G型抗体的血清浓度

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Several studies suggest that infection by Epstein-Barr virus (EBV) might be one of the environmental factors which facilitates the development of autoimmune disorders in genetically susceptible individuals. Recent data indicate that high anti-Epstein-Barr nuclear antigen 1 (EBNA)-1 immunoglobulin (Ig)G titre is a strong risk factor for multiple sclerosis (MS) in patients both with and without the main genetic predisposing trait, human leucocyte antigen (HLA)-DRB1*15:01. Because no similar studies have been published in systemic lupus erythematosus (SLE) patients, we determined the HLA-DRB1*15:01 carrier state and the serum titres against the whole EBNA-1 and its small fragments aa35-58 and aa398-404 in 301 SLE patients, 135MS patients and in 345 healthy controls. The carrier state of the HLA-DRB1*15:01 allele was deduced from genotyping of a tagSNP (rs3135388) by applying a Taqman-based assay. The serum concentrations of antibodies to EBNA-1 and its aa35-58 or aa398-404 fragments were determined using a commercial assay (ETI-EBNA-G) and home-made enzyme-linked immunosorbent assays, respectively. The serum concentration of anti-EBNA-1 antibodies was significantly (P<0??001) higher both in MS and SLE patients than in controls. Similar significant differences were found both in HLA-DRB1*15:01 carriers and non-carriers. Furthermore, titres of antibodies against the aa35-58 EBNA-1 fragment were elevated both in MS and SLE patients. By contrast, the levels of aa398-404 EBNA-1 antibodies were elevated significantly only in the SLE patients. These findings indicate that high anti-EBNA-1 IgG titres are HLA-DRB1*15:01-independent risk factors not only for MS, but also for SLE, while high antibody titres against the aa398-404 fragment are characteristic for SLE. ? 2012 British Society for Immunology.
机译：多项研究表明，爱泼斯坦-巴尔病毒（EBV）感染可能是促进遗传易感人群自身免疫性疾病发展的环境因素之一。最新数据表明，高抗-Epstein-Barr核抗原1（EBNA）-1免疫球蛋白（Ig）G滴度是有和没有主要遗传易感性指标（人类白细胞抗原）的患者发生多发性硬化（MS）的强大危险因素（HLA）-DRB1 * 15：01。由于尚未在系统性红斑狼疮（SLE）患者中发表类似研究，因此我们确定了HLA-DRB1 * 15：01携带者的状态以及针对整个EBNA-1及其小片段aa35-58和aa398-404的血清滴度。 301名SLE患者，135MS患者和345名健康对照者。 HLA-DRB1 * 15：01等位基因的携带者状态是通过基于Taqman的分析从tagSNP（rs3135388）的基因分型推导出来的。分别使用商业化测定（ETI-EBNA-G）和自制的酶联免疫吸附测定法确定了针对EBNA-1及其aa35-58或aa398-404片段的抗体的血清浓度。 MS和SLE患者的抗EBNA-1抗体的血清浓度均显着高于对照组（P <0≤001）。在HLA-DRB1 * 15：01载波和非载波中都发现了相似的显着差异。此外，在MS和SLE患者中，针对aa35-58 EBNA-1片段的抗体的滴度均升高。相比之下，aa398-404 EBNA-1抗体的水平仅在SLE患者中显着升高。这些发现表明，高抗EBNA-1 IgG滴度不仅对MS，而且对SLE都是HLA-DRB1 * 15：01独立的危险因素，而针对aa398-404片段的高抗体滴度是SLE的特征。 ？ 2012年英国免疫学会。

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