HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF SIMVASTATIN IN DRUGS MEDICINES

Eyad S. M. Abu-Nameh; Reyad A. Shawabkeh; Azzam Ali

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HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF SIMVASTATIN IN DRUGS MEDICINES

机译：高效液相色谱法测定药物中辛伐他汀的含量

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A simple and rapid HPLC method for the determination of simvastatin using C18-Hypersil column and acetonitril-phosphatebuffer-methanol (5:3:1, v/v/v) as mobile phase with detection at 230 nm was proposed. Commercial pharmaceutical tablets were analyzed with a linear range for simvastatin up to 1.884 mg% and a regression coefficient of 0.9995. The method is found to be precise, accurate, reliable and selective.

机译：提出了一种简单快速的HPLC方法，以C18-Hypersil色谱柱和乙腈-磷酸盐缓冲液-甲醇（5：3：1，v / v / v）作为流动相，测定辛伐他汀，检测波长为230 nm。辛伐他汀的线性范围高达1.884 mg％，回归系数为0.9995，对商用药物片剂进行了分析。发现该方法是精确，准确，可靠和选择性的。

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《Журнал аналитической химии》 |2006年第1期|共4页
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Eyad S. M. Abu-Nameh; Reyad A. Shawabkeh; Azzam Ali;
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正文语种 eng
中图分类分析化学;
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1. HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF SIMVASTATIN IN DRUGS MEDICINES [J] . Eyad S. M. Abu-Nameh, Reyad A. Shawabkeh, Azzam Ali Журнал аналитической химии . 2006,第1期

机译：高效液相色谱法测定药物中辛伐他汀的含量
2. High-performance liquid chromatographic determination of simvastatin in medical drugs [J] . Abu-Nameh ESM, Shawabkeh RA, Ali A Journal of analytical chemistry . 2006,第1期

机译：高效液相色谱法测定药物中辛伐他汀的含量
3. Stability-indicating reversed-phase liquid chromatographic method for simultaneous determination of simvastatin and ezetimibe from their combination drug products [J] . Chaudhari BG, Patel NM, Shah PB Journal of AOAC International . 2007,第5期

机译：稳定指示反相液相色谱法同时测定其组合药物中辛伐他汀和依泽替米贝的含量
4. the classification of 252 drugs in reversedphase high performance liquid chromatogra-phy and the rules of their chromatographic behavior [C] . Beijing conference and exhibition on instrumental analysis;BCEIA . 2001

机译：反相高效液相色谱法对252种药物的分类及其色谱行为规律
5. Stability-indicating reversed-phase high performance liquid chromatographic method for the assay of Loratadine and determination of impurities/degradants in its raw material. [D] . Tahmisoglu, Gulustan S. 2015

机译：用于氯雷他定测定及原料中杂质/降解物含量测定的稳定性指示反相高效液相色谱法。
6. Development and Validation of a Stability-Indicating High Performance Liquid Chromatographic (HPLC) Method for the Determination of Related Substances of Micafungin Sodium in Drug Substances [O] . Shengsheng Zhu, Xiang Meng, Xin Su, 2013

机译：稳定性指示高效液相色谱法测定药物中米卡芬净钠相关物质的开发与验证
7. High performance liquid chromatographic determination of carnitine hydrochloride in herbal liquores used as gastrointestinal medicines. [O] . FUJIO WATANABE, MASAZOU ISHINO, YOSHIFUMI HIROSE, 1991

机译：用作胃肠药物中草液中盐酸肉碱的高效液相色谱法测定。
8. Ion-Pair High-Performance Liquid Chromatographic Separation of a Multicomponent Anticholinergic Drug Formulation. [R] . Brown, N. D., Hall, L. L., Sleeman, H. K., 1977

机译：离子对高效液相色谱分离多组分抗胆碱能药物配方。

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF SIMVASTATIN IN DRUGS MEDICINES

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