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首页> 外文期刊>Журнал аналитической химии >A SIMPLE SPECTROPHOTOMETRY PROCEDURE FOR DETERMINATION OF VALACICLOVIR IN DOSAGE FORMSAND BIOLOGICAL FLUIDS
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A SIMPLE SPECTROPHOTOMETRY PROCEDURE FOR DETERMINATION OF VALACICLOVIR IN DOSAGE FORMSAND BIOLOGICAL FLUIDS

机译：分光光度法测定剂量形式和生物流体中缬氨酸的含量。

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摘要

A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton—Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 x 10 6 to 6 x Ю-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.
机译：提出了一种简单，选择性的分光光度法测定缬氨酸洛韦尔（VALA）的方法，并将其用于测定片剂和生物液体中的物质。建议使用此程序测定pH 6.0的Britton-Robinson（BR）缓冲液中的VALA，该值可在4 x 10 6至6 xЮ-5M范围内进行定量，用于分光光度法测量。估计了该过程对于血清和母乳样品的可重复性和可重复性。还检查精度和准确性。标准添加方法用于生物液体。验证了所提议的产品可用于测定真实人血清，母乳样品中的VALA;发现对代谢物的选择性非常令人满意。

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