In silico analysis for transcription factors with Zn(II)2C6 binuclear cluster DNA-binding domains in Candida albicans

Sergi Maicas; Inmaculada Moreno; Almudena Nieto; Micaela Gomez; Rafael Sentandreu; Eulogio Valentín

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In silico analysis for transcription factors with Zn(II)2C6 binuclear cluster DNA-binding domains in Candida albicans

机译：在计算机上分析白色念珠菌中具有Zn（II）2C6双核簇DNA结合结构域的转录因子

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A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)2C6-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX2CysX6CysX5-16CysX2CysX6-8Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)2C6 transcription factors have been found in the genome of C. albicans.

机译：筛选白色念珠菌基因组中总共6047个开放阅读框，寻找涉及DNA识别的Zn（II）2C6型锌簇蛋白（或双核簇蛋白）。这些真菌蛋白是涉及广泛细胞过程的基因的转录调节因子，包括糖或氨基酸等不同化合物的代谢以及多药耐药性，减数分裂的控制，细胞壁结构等。选择标准序列分析中使用的是CysX2CysX6CysX5-16CysX2CysX6-8Cys基序的存在和假定的核定位信号。使用这种方法，在白色念珠菌的基因组中发现了70个推定的Zn（II）2C6转录因子。

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来源
《Comparative and functional genomics》 |2005年第8期|共12页
作者
Sergi Maicas; Inmaculada Moreno; Almudena Nieto; Micaela Gomez; Rafael Sentandreu; Eulogio Valentín;
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正文语种 eng
中图分类分子生物学;
关键词
Candida albicans; transcription factor; Zn(II)2C6 domain; binuclear cluster proteins;

机译：白色念珠菌;转录因子;Zn（II）2C6结构域;双核簇蛋白;

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1. In silico analysis for transcription factors with Zn(II)2C6 binuclear cluster DNA-binding domains in Candida albicans [J] . Sergi Maicas, Inmaculada Moreno, Almudena Nieto, Comparative and functional genomics . 2005,第7a8期

机译：在计算机上分析白色念珠菌中具有Zn（II）2C6双核簇DNA结合结构域的转录因子
2. Novel fungal transcriptional activators, Cmr1p of Colletotrichum lagenarium and pig1p of Magnaporthe grisea, contain Cys2His2 zinc finger and Zn(II)2Cys6 binuclear cluster DNA-binding motifs and regulate transcription of melanin biosynthesis genes in [J] . Tsuji G, Kenmochi Y, Takano Y, Molecular Microbiology . 2000,第5期

机译：新型的真菌转录激活因子，Colrotrichum lagenarium的Cmr1p和稻瘟病菌的Pig1p，包含Cys2His2锌指和Zn（II）2Cys6双核簇DNA结合基序，并调控黑色素生物合成基因的转录。
3. Candida albicans Zn Cluster Transcription Factors Tac1 and Znc1 Are Activated by Farnesol To Upregulate a Transcriptional Program Including the Multidrug Efflux Pump CDR1 [J] . Liu Zhongle, Rossi John M., Myers Lawrence C. Antimicrobial agents and chemotherapy. . 2018,第11期

机译：Candida albicans Zn聚类转录因子TAC1和ZNC1由法内尔尼激活，以上调包括MultiDrug Efflux泵CDR1的转录程序
4. Systematic DNA-Binding Domain Classification of Transcription Factors [C] . Philip Stegmaier, Alexander E. Kel, Edgar Wingender International Workshop on Bioinformatics and Systems Biology . 2004

机译：系统的DNA结合结构域转录因子分类
5. CCAAT-Binding Factor as a Transcriptional Regulator of CYC1 in Candida albicans. [D] . Padilla-Marcia, Carmen S. 2013

机译：CCAAT结合因子作为白色念珠菌中CYC1的转录调节因子。
6. In Silico Analysis for Transcription Factors With Zn(II)2C6 Binuclear Cluster DNA-Binding Domains in Candida albicans [O] . Sergi Maicas, Inmaculada Moreno, Almudena Nieto, 2005

机译：在计算机模拟中分析白色念珠菌中具有Zn（II）2C6双核簇DNA结合域的转录因子
7. In Silico Analysis for Transcription Factors With Zn(II)2C6 Binuclear Cluster DNA-Binding Domains in Candida albicans [O] . Eulogio Valentí, Rafael Sentandreu, Micaela Gó, 2006

机译：在计算机模拟中分析白色念珠菌中具有Zn（II）2C6双核簇DNA结合域的转录因子

In silico analysis for transcription factors with Zn(II)2C6 binuclear cluster DNA-binding domains in Candida albicans

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